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globalchange > 过去全球变化的重建

DOI:	10.1371/journal.pone.0164861
论文题名:	Epidemiology and Surveillance of Influenza Viruses in Uganda between 2008 and 2014
作者:	Fred Wabwire-Mangen; Derrick E. Mimbe; Bernard Erima; Edison A. Mworozi; Monica Millard; Hannah Kibuuka; Luswa Lukwago; Josephine Bwogi; Jocelyn Kiconco; Titus Tugume; Sophia Mulei; Christine Ikomera; Sharon Tsui; Stephen Malinzi; Simon Kasasa; Rodney Coldren; Denis K. Byarugaba
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2016
发表日期:	2016-10-18
卷:	11, 期:10
语种:	英语
英文关键词:	Influenza ; Influenza A virus ; Infectious disease surveillance ; Influenza viruses ; Seasons ; Uganda ; Influenza B virus ; Swine influenza
英文摘要:	Introduction Influenza surveillance was conducted in Uganda from October 2008 to December 2014 to identify and understand the epidemiology of circulating influenza strains in out-patient clinic attendees with influenza-like illness and inform control strategies. Methodology Surveillance was conducted at five hospital-based sentinel sites. Nasopharyngeal and/or oropharyngeal samples, epidemiological and clinical data were collected from enrolled patients. Real-time reverse transcription polymerase chain reaction (RT-PCR) was performed to identify and subtype influenza strains. Data were double-entered into an Epi Info 3.5.3 database and exported to STATA 13.0 software for analysis. Results Of the 6,628 patient samples tested, influenza virus infection was detected in 10.4% (n = 687/6,628) of the specimens. Several trends were observed: influenza circulates throughout the year with two peaks; the major one from September to November and a minor one from March to June. The predominant strains of influenza varied over the years: Seasonal Influenza A(H3) virus was predominant from 2008 to 2009 and from 2012 to 2014; Influenza A(H1N1)pdm01 was dominant in 2010; and Influenza B virus was dominant in 2011. The peaks generally coincided with times of higher humidity, lower temperature, and higher rainfall. Conclusion Influenza circulated throughout the year in Uganda with two major peaks of outbreaks with similar strains circulating elsewhere in the region. Data on the circulating strains of influenza and its patterns of occurrence provided critical insights to informing the design and timing of influenza vaccines for influenza prevention in tropical regions of sub-Saharan Africa.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0164861&type=printable
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资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/24047
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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作者单位:

Makerere University, School of Public Health, College of Health Sciences, Kampala, Uganda;Makerere University Walter Reed Project, Kampala, Uganda;Makerere University Walter Reed Project, Kampala, Uganda;Makerere University Walter Reed Project, Kampala, Uganda;Makerere University, School of Public Health, College of Health Sciences, Kampala, Uganda;Makerere University Walter Reed Project, Kampala, Uganda;Makerere University Walter Reed Project, Kampala, Uganda;Ministry of Health, Kampala, Uganda;Uganda Virus Research Institute, Entebbe, Uganda;Makerere University Walter Reed Project, Kampala, Uganda;Makerere University Walter Reed Project, Kampala, Uganda;Makerere University Walter Reed Project, Kampala, Uganda;Makerere University Walter Reed Project, Kampala, Uganda;John Hopkins University, Baltimore, Maryland, United States of America;Makerere University Walter Reed Project, Kampala, Uganda;Makerere University, School of Public Health, College of Health Sciences, Kampala, Uganda;United States Army Medical Research Directorate—Kenya, Nairobi, Kenya;Makerere University Walter Reed Project, Kampala, Uganda;Makerere University, College of Veterinary Medicine, Animal Resources and Biosecurity, Kampala, Uganda

Recommended Citation:

Fred Wabwire-Mangen,Derrick E. Mimbe,Bernard Erima,et al. Epidemiology and Surveillance of Influenza Viruses in Uganda between 2008 and 2014[J]. PLOS ONE,2016-01-01,11(10)

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