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DOI:	10.1371/journal.pone.0153761
论文题名:	Phylogenetic Analysis and Epidemic History of Hepatitis C Virus Genotype 2 in Tunisia, North Africa
作者:	Mouna Rajhi; Kais Ghedira; Anissa Chouikha; Ahlem Djebbi; Imed Cheikh; Ahlem Ben Yahia; Amel Sadraoui; Walid Hammami; Msaddek Azouz; Nabil Ben Mami; Henda Triki
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2016
发表日期:	2016-4-21
卷:	11, 期:4
语种:	英语
英文关键词:	Tunisia ; Phylogenetic analysis ; Sequence analysis ; DNA sequence analysis ; Italy ; Phylogeography ; Hepatitis C virus ; Genetic epidemiology
英文摘要:	HCV genotype 2 (HCV-2) has a worldwide distribution with prevalence rates that vary from country to country. High genetic diversity and long-term endemicity were suggested in West African countries. A global dispersal of HCV-2 would have occurred during the 20th century, especially in European countries. In Tunisia, genotype 2 was the second prevalent genotype after genotype 1 and most isolates belong to subtypes 2c and 2k. In this study, phylogenetic analyses based on the NS5B genomic sequences of 113 Tunisian HCV isolates from subtypes 2c and 2k were carried out. A Bayesian coalescent-based framework was used to estimate the origin and the spread of these subtypes circulating in Tunisia. Phylogenetic analyses of HCV-2c sequences suggest the absence of country-specific or time-specific variants. In contrast, the phylogenetic grouping of HCV-2k sequences shows the existence of two major genetic clusters that may represent two distinct circulating variants. Coalescent analysis indicated a most recent common ancestor (tMRCA) of Tunisian HCV-2c around 1886 (1869–1902) before the introduction of HCV-2k in 1901 (1867–1931). Our findings suggest that the introduction of HCV-2c in Tunisia is possibly a result of population movements between Tunisia and European population following the French colonization.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0153761&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/24090
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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File Name/ File Size	Content Type	Version	Access	License
journal.pone.0153761.PDF（2912KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

Pasteur Institute, Tunis, Tunisia; Laboratory of Clinical Virology, WHO Regional Reference Laboratory on Poliomyelitis and Measles, Tunis, Tunisia;University of Carthage, Faculty of Sciences, Bizerte, Tunisia;Pasteur Institute, Tunis, Tunisia; Laboratory of Bioinformatics, Mathematics and Statistics, Tunis, Tunisia;University of Tunis El Manar, Tunis, 1036, Tunisia;Pasteur Institute, Tunis, Tunisia; Laboratory of Clinical Virology, WHO Regional Reference Laboratory on Poliomyelitis and Measles, Tunis, Tunisia;Pasteur Institute, Tunis, Tunisia; Laboratory of Clinical Virology, WHO Regional Reference Laboratory on Poliomyelitis and Measles, Tunis, Tunisia;Department of Gastroenterology, Regional Hospital of Bizerte, Bizerte, Tunisia;Pasteur Institute, Tunis, Tunisia; Laboratory of Clinical Virology, WHO Regional Reference Laboratory on Poliomyelitis and Measles, Tunis, Tunisia;Pasteur Institute, Tunis, Tunisia; Laboratory of Clinical Virology, WHO Regional Reference Laboratory on Poliomyelitis and Measles, Tunis, Tunisia;Pasteur Institute, Tunis, Tunisia; Laboratory of Clinical Virology, WHO Regional Reference Laboratory on Poliomyelitis and Measles, Tunis, Tunisia;Department of Gastroenterology, Regional Hospital of Nabeul, Nabeul, Tunisia;Department of Gastroenterology, La Rabta Hospital, Tunis, Tunisia;Pasteur Institute, Tunis, Tunisia; Laboratory of Clinical Virology, WHO Regional Reference Laboratory on Poliomyelitis and Measles, Tunis, Tunisia;University of Tunis El Manar, Tunis, 1036, Tunisia

Recommended Citation:

Mouna Rajhi,Kais Ghedira,Anissa Chouikha,et al. Phylogenetic Analysis and Epidemic History of Hepatitis C Virus Genotype 2 in Tunisia, North Africa[J]. PLOS ONE,2016-01-01,11(4)

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