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globalchange > 过去全球变化的重建

DOI:	10.1371/journal.pone.0149017
论文题名:	Genome-Wide Diversity and Phylogeography of Mycobacterium avium subsp. paratuberculosis in Canadian Dairy Cattle
作者:	Christina Ahlstrom; Herman W. Barkema; Karen Stevenson; Ruth N. Zadoks; Roman Biek; Rowland Kao; Hannah Trewby; Deb Haupstein; David F. Kelton; Gilles Fecteau; Olivia Labrecque; Greg P. Keefe; Shawn L. B. McKenna; Kapil Tahlan; Jeroen De Buck
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2016
发表日期:	2016-2-12
卷:	11, 期:2
语种:	英语
英文关键词:	Phylogeography ; Phylogenetics ; Phylogenetic analysis ; Livestock ; Alberta ; Canada ; Cattle ; Gene mapping
英文摘要:	Mycobacterium avium subsp. paratuberculosis (MAP) is the causative bacterium of Johne’s disease (JD) in ruminants. The control of JD in the dairy industry is challenging, but can be improved with a better understanding of the diversity and distribution of MAP subtypes. Previously established molecular typing techniques used to differentiate MAP have not been sufficiently discriminatory and/or reliable to accurately assess the population structure. In this study, the genetic diversity of 182 MAP isolates representing all Canadian provinces was compared to the known global diversity, using single nucleotide polymorphisms identified through whole genome sequencing. MAP isolates from Canada represented a subset of the known global diversity, as there were global isolates intermingled with Canadian isolates, as well as multiple global subtypes that were not found in Canada. One Type III and six “Bison type” isolates were found in Canada as well as one Type II subtype that represented 86% of all Canadian isolates. Rarefaction estimated larger subtype richness in Québec than in other Canadian provinces using a strict definition of MAP subtypes and lower subtype richness in the Atlantic region using a relaxed definition. Significant phylogeographic clustering was observed at the inter-provincial but not at the intra-provincial level, although most major clades were found in all provinces. The large number of shared subtypes among provinces suggests that cattle movement is a major driver of MAP transmission at the herd level, which is further supported by the lack of spatial clustering on an intra-provincial scale.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0149017&type=printable
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资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/24103
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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journal.pone.0149017.PDF（1562KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

University of Calgary, Calgary, Alberta, Canada;University of Calgary, Calgary, Alberta, Canada;Moredun Research Institute, Penicuik, Scotland;Moredun Research Institute, Penicuik, Scotland;University of Glasgow, Glasgow, Scotland;University of Glasgow, Glasgow, Scotland;University of Glasgow, Glasgow, Scotland;University of Glasgow, Glasgow, Scotland;SaskMilk, Regina, Saskatchewan, Canada;University of Guelph, Guelph, Ontario, Canada;Université de Montréal, Montréal, Québec, Canada;Laboratoire d'épidémiosurveillance animale du Québec, Saint-Hyacinthe, Québec, Canada;University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada;University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada;Memorial University of Newfoundland and Labrador, St. John’s, Newfoundland, Canada;University of Calgary, Calgary, Alberta, Canada

Recommended Citation:

Christina Ahlstrom,Herman W. Barkema,Karen Stevenson,et al. Genome-Wide Diversity and Phylogeography of Mycobacterium avium subsp. paratuberculosis in Canadian Dairy Cattle[J]. PLOS ONE,2016-01-01,11(2)

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