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globalchange > 过去全球变化的重建

DOI:	10.1371/journal.pone.0164265
论文题名:	The Phylogeographic and Spatiotemporal Spread of HCV in Pakistani Population
作者:	Noor-Ul-Huda Ghori; Atif Shafique; Muhammad Qasim Hayat; Sadia Anjum
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2016
发表日期:	2016-10-20
卷:	11, 期:10
语种:	英语
英文关键词:	Phylogenetic analysis ; Pakistan ; Phylogenetics ; Viral evolution ; Evolutionary genetics ; Hepatitis C virus ; Sequence analysis ; Phylogeography
英文摘要:	Hepatitis C Virus (HCV) is the most prevalent human pathogen in Pakistan and is the major cause of liver cirrhosis and hepatocellular carcinoma in infected patients. It has shifted from being hypo-endemic to being hyper-endemic. There was no information about the origin and evolution of the local variants. Here we use newly developed phyloinformatic methods of sequence analysis to conduct the first comprehensive investigation of the evolutionary and biogeographic history in unprecedented detail and breadth. Considering evolutionary rate and molecular-clock hypothesis in context, we reconstructed the spatiotemporal spread of HCV in the whole territory of its circulation using a combination of Bayesian MCMC methods utilizing all sequences available in GenBank. Comparative analysis were performed and were addressed. Whole genome and individual gene analysis have shown that sub-types 1a, 1b and 3a are recognized as epidemic strains and are distributed globally. Here we confirm that the origin of HCV 3a genotypes is in South Asia and HCV has evolved in the region to become stably adapted to the host environment.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0164265&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/24115
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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journal.pone.0164265.PDF（2712KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

School of Earth and Environment, The University of Western Australia, Perth, Australia;Atta-Ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan;Atta-Ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan;Atta-Ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan;Atta-Ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan;Department of Biology, College of Sciences, University Of Hail, PO Box 2440, Hail, Kingdom of Saudi Arabia

Recommended Citation:

Noor-Ul-Huda Ghori,Atif Shafique,Muhammad Qasim Hayat,et al. The Phylogeographic and Spatiotemporal Spread of HCV in Pakistani Population[J]. PLOS ONE,2016-01-01,11(10)

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