globalchange  > 过去全球变化的重建
DOI: 10.1371/journal.pone.0162112
论文题名:
High Prevalence and Onward Transmission of Non-Pandemic HIV-1 Subtype B Clades in Northern and Northeastern Brazilian Regions
作者: Flavia Divino; Andre de Lima Guerra Corado; Felipe Gomes Naveca; Mariane M. A. Stefani; Gonzalo Bello
刊名: PLOS ONE
ISSN: 1932-6203
出版年: 2016
发表日期: 2016-9-7
卷: 11, 期:9
语种: 英语
英文关键词: HIV-1 ; Brazil ; Caribbean ; Sequence analysis ; Phylogenetic analysis ; Sequence databases ; Guyana ; Phylogeography
英文摘要: The Human immunodeficiency virus type-1 (HIV-1) epidemic in Brazil is mainly driven by the subtype B pandemic lineage (BPANDEMIC), while Caribbean non-pandemic subtype B clades (BCAR) seem to account for a very low fraction of HIV-infections in this country. The molecular characteristics of the HIV-1 subtype B strains disseminated in the Northern and Northeastern Brazilian regions, however, have not been explored so far. In this study, we estimate the prevalence of the HIV-1 BPANDEMIC and BCAR clades across different Brazilian regions and we reconstruct the spatiotemporal dynamics of dissemination of the major Brazilian BCAR clades. A total of 2,682 HIV-1 subtype B pol sequences collected from 21 different Brazilian states from the five country regions between 1998 and 2013 were analyzed. Maximum Likelihood phylogenetic analyses revealed that the BCAR strains reached 16 out 21 Brazilian states here analyzed. The BCAR clades comprise a low fraction (<10%) of subtype B infections in most Brazilian states analyzed, with exception of Roraima (41%), Amazonas (14%) and Maranhão (14%). Bayesian phylogeographic analyses indicate that BCAR strains originally from the Hispaniola and Trinidad and Tobago were introduced at multiple times into different states from all Brazilian regions and a few of those strains, probably introduced into Roraima, Maranhão and São Paulo between the late 1970s and the early 1980s, established secondary outbreaks in the Brazilian population. These results support that the HIV-1 subtype B epidemics in some Brazilian states from the Northern and Northeastern regions display a unique molecular pattern characterized by the high prevalence of BCAR lineages, which probably reflects a strong epidemiological link with the HIV-1 epidemics in the Caribbean region.
URL: http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0162112&type=printable
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/24116
Appears in Collections:过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响

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作者单位: Laboratório de AIDS e Imunologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brazil;Instituto Leônidas e Maria Deane, Fundação Oswaldo Cruz, Manaus, AM, Brazil;Instituto Leônidas e Maria Deane, Fundação Oswaldo Cruz, Manaus, AM, Brazil;Tropical Pathology and Public Health Institute, Federal University of Goiás, Goiânia, GO, Brazil;Laboratório de AIDS e Imunologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brazil

Recommended Citation:
Flavia Divino,Andre de Lima Guerra Corado,Felipe Gomes Naveca,et al. High Prevalence and Onward Transmission of Non-Pandemic HIV-1 Subtype B Clades in Northern and Northeastern Brazilian Regions[J]. PLOS ONE,2016-01-01,11(9)
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