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DOI:	10.1371/journal.pone.0169578
论文题名:	Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin
作者:	Fangfang Xu; Qiuxia Yang; Lilan Wu; Rui Qi; Yunshan Wu; Yucui Li; Lipeng Tang; De-an Guo; Bo Liu
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2017
发表日期:	2017-1-17
卷:	12, 期:1
语种:	英语
英文关键词:	Solubility ; Alcohols ; Thermal stability ; Gas chromatography-mass spectrometry ; Humidity ; Molecular structure ; X-ray diffraction ; Scanning electron microscopes
英文摘要:	The objective of this study was to improve the stability and water-solubility of patchouli alcohol by complexing with β-cyclodextrin (β-CD). The interactions between patchouli alcohol and β-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation-infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. According to molecular modeling method, the enthalpy formation of host-guest illustrated the predominant configuration and the lowest value ΔbGo was -10.8174±1.9235 kcal/mol, suggesting the complex could reduce the energy of the system. The characterization analysis confirmed the formation of PA-CD inclusion complex, and the results indicated the advantage of the inclusion complex in stability and dissolution rates. These results identified PA-CD inclusion complex an effective way for the storage of PA, and better inclusion method still needed to be studied.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0169578&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/25950
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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File Name/ File Size	Content Type	Version	Access	License
journal.pone.0169578.pdf（1940KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China;Guangdong Pharmaceutical University, College of Traditional Chinese Medicine, Guangzhou, China;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China;College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou, China;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China;Guangdong Pharmaceutical University, College of Traditional Chinese Medicine, Guangzhou, China;Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, China;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

Recommended Citation:

Fangfang Xu,Qiuxia Yang,Lilan Wu,et al. Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin[J]. PLOS ONE,2017-01-01,12(1)

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