| DOI: | 10.7249/RR1520
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| 报告号: | RR-1520-RE
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| 报告题名: | Population-scale sequencing and the future of genomic medicine: Learning from past and present efforts |
| 作者: | Talitha Dubow; Sonja Marjanovic
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| 出版者: | RAND Corporation
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| 出版年: | 2016
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| 发表日期: | 2016
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| 总页数: | 78
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| 国家: | 美国
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| 语种: | 英语
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| 英文关键词: | Bioethics
; Populations
; Genomic Medicine
; Health Care Technology
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| 英文摘要: | Genomic medicine, as a field, has the potential to change the way we prevent, manage and treat disease. Although the routine implementation of genomic medicine in clinical care is yet to be realised, diverse national and international initiatives are narrowing the gap between prospect and practice. This paper provides a reflection on the variety of population-scale genome-sequencing efforts that have emerged over the past two decades and examines their social implications. We analyse the progress these initiatives have made, both in terms of their scientific, technological and biomedical contributions, and in terms of their influence on the institutions that govern science and innovation more widely. Based on our analysis, we identify five areas of action for a future research and policy agenda to consider. These span issues related to: i) the scale-up of existing efforts and the need for more cross-sector collaboration for clinically-relevant sense-making; ii) the implications of genomics in clinical settings; iii) changes in industry R&D models that are likely to accompany further advances in genomic medicine; iv) consolidating learning about appropriate research ethics frameworks and clarifying the legal arrangements necessary for genomic medicine; and v) wider evaluation and learning from past and current efforts. |
| URL: | http://www.rand.org/content/dam/rand/pubs/research_reports/RR1500/RR1520/RAND_RR1520.pdf
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| Citation statistics: |
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| 资源类型: | 研究报告
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/27183
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| Appears in Collections: | 影响、适应和脆弱性
科学计划与规划
气候减缓与适应
气候变化事实与影响
气候变化与战略
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| RAND_RR1520.pdf（848KB） | 研究报告 | -- | 开放获取 | | View
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| Recommended Citation: | |
Talitha Dubow,Sonja Marjanovic. Population-scale sequencing and the future of genomic medicine: Learning from past and present efforts. 2016-01-01.
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