| DOI: | 10.2172/1098145
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| 报告号: | 105016100
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| 报告题名: | Deduction and Analysis of the Interacting Stress Response Pathways of Metal/Radionuclide-reducing Bacteria |
| 作者: | Zhou, Jizhong [University of Oklahoma]; He, Zhili [University of Oklahoma]
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| 出版年: | 2010
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| 发表日期: | 2010-02-28
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| 国家: | 美国
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| 语种: | 英语
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| 英文关键词: | stress response pathways
; metal/radionuclide-reducing bacteria
; functional genomics
; Desulfovibrio vugaris
; environmental stresses
; metagenomics technologies
; microbial communities
; functional gene arrays
; metal reduction
; bioremediation
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| 英文摘要: | Project Title: Deduction and Analysis of the Interacting Stress Response Pathways of Metal/Radionuclide-reducing Bacteria DOE Grant Number: DE-FG02-06ER64205 Principal Investigator: Jizhong (Joe) Zhou (University of Oklahoma) Key members: Zhili He, Aifen Zhou, Christopher Hemme, Joy Van Nostrand, Ye Deng, and Qichao Tu Collaborators: Terry Hazen, Judy Wall, Adam Arkin, Matthew Fields, Aindrila Mukhopadhyay, and David Stahl Summary Three major objectives have been conducted in the Zhou group at the University of Oklahoma (OU): (i) understanding of gene function, regulation, network and evolution of Desulfovibrio vugaris Hildenborough in response to environmental stresses, (ii) development of metagenomics technologies for microbial community analysis, and (iii) functional characterization of microbial communities with metagenomic approaches. In the past a few years, we characterized four CRP/FNR regulators, sequenced ancestor and evolved D. vulgaris strains, and functionally analyzed those mutated genes identified in salt-adapted strains. Also, a new version of GeoChip 4.0 has been developed, which also includes stress response genes (StressChip), and a random matrix theory-based conceptual framework for identifying functional molecular ecological networks has been developed with the high throughput functional gene array hybridization data as well as pyrosequencing data from 16S rRNA genes. In addition, GeoChip and sequencing technologies as well as network analysis approaches have been used to analyze microbial communities from different habitats. Those studies provide a comprehensive understanding of gene function, regulation, network, and evolution in D. vulgaris, and microbial community diversity, composition and structure as well as their linkages with environmental factors and ecosystem functioning, which has resulted in more than 60 publications. |
| URL: | http://www.osti.gov/scitech/servlets/purl/1098145
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| Citation statistics: |
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| 资源类型: | 研究报告
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/39586
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| Appears in Collections: | 过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响
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| 1098145.pdf（246KB） | 研究报告 | -- | 开放获取 | | View
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| Recommended Citation: | |
Zhou, Jizhong [University of Oklahoma],He, Zhili [University of Oklahoma]. Deduction and Analysis of the Interacting Stress Response Pathways of Metal/Radionuclide-reducing Bacteria. 2010-01-01.
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