| DOI: | 10.2172/1093865
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| 报告号: | DOE-CSU--63946-3
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| 报告题名: | Radiation Leukemogenesis at Low Dose Rates |
| 作者: | Weil, Michael; Ullrich, Robert
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| 出版年: | 2013
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| 发表日期: | 2013-09-25
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| 总页数: | 14
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| 国家: | 美国
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| 语种: | 英语
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| 英文关键词: | low dose rate radiation
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| 英文摘要: | The major goals of this program were to study the efficacy of low dose rate radiation exposures for the induction of acute myeloid leukemia (AML) and to characterize the leukemias that are caused by radiation exposures at low dose rate. An irradiator facility was designed and constructed that allows large numbers of mice to be irradiated at low dose rates for protracted periods (up to their life span). To the best of our knowledge this facility is unique in the US and it was subsequently used to study radioprotectors being developed for radiological defense (PLoS One. 7(3), e33044, 2012) and is currently being used to study the role of genetic background in susceptibility to radiation-induced lung cancer. One result of the irradiation was expected; low dose rate exposures are ineffective in inducing AML. However, another result was completely unexpected; the irradiated mice had a very high incidence of hepatocellular carcinoma (HCC), approximately 50%. It was unexpected because acute exposures are ineffective in increasing HCC incidence above background. This is a potential important finding for setting exposure limits because it supports the concept of an 'inverse dose rate effect' for some tumor types. That is, for the development of some tumor types low dose rate exposures carry greater risks than acute exposures. |
| URL: | http://www.osti.gov/scitech/servlets/purl/1093865
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| Citation statistics: |
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| 资源类型: | 研究报告
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/40986
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| Appears in Collections: | 过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响
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| 1093865.pdf（630KB） | 研究报告 | -- | 开放获取 | | View
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| Recommended Citation: | |
Weil, Michael,Ullrich, Robert. Radiation Leukemogenesis at Low Dose Rates. 2013-01-01.
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