| DOI: | 10.2172/1160350
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| 报告号: | Final report
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| 报告题名: | Neurodegeneration and adaptation in response to low-dose photon irradiation |
| 作者: | Limoli, Charles L.
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| 出版年: | 2014
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| 发表日期: | 2014-10-27
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| 国家: | 美国
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| 语种: | 英语
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| 英文关键词: | Low dose radiation
; adpatation
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| 英文摘要: | Neural stem and precursor cells (i.e. multipotent neural cells) are concentrated in the neurogenic regions of the brain (hippocampal dentate gyrus, subventricular zones), and considerable evidence suggests that these cells are important in mediating the stress response of the CNS after damage from ionizing radiation. The capability of these cells to proliferate, migrate and differentiate (i.e. to undergo neurogenesis) suggests they can participate in the repair and maintenance of CNS functions by replacing brain cells damaged or depleted due to irradiation. Importantly, we have shown that multipotent neural cells are markedly sensitive to irradiation and oxidative stress, insults that compromise neurogenesis and hasten the onset and progression of degenerative processes that are likely to have an adverse impact on cognition. Our past and current work has demonstrated that relatively low doses of radiation cause a persistent (weeks-months) oxidative stress in multipotent neural cells that can elicit a range of degenerative sequelae in the CNS. Therefore, our project is focused on determining the extent that endogenous and redox sensitive multipotent neural cells represent important radioresponsive targets for low dose radiation effects. We hypothesize that the activation of redox sensitive signaling can trigger radioadaptive changes in these cells that can be either harmful or beneficial to overall cognitive health. |
| URL: | http://www.osti.gov/scitech/servlets/purl/1160350
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| Citation statistics: |
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| 资源类型: | 研究报告
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/41387
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| Appears in Collections: | 过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响
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| 1160350.pdf（148KB） | 研究报告 | -- | 开放获取 | | View
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| Recommended Citation: | |
Limoli, Charles L.. Neurodegeneration and adaptation in response to low-dose photon irradiation. 2014-01-01.
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