| DOI: | 10.2172/1239176
|
| 报告号: | LLNL--TR-682042
|
| 报告题名: | Mechanism for Clastogenic Activity of Naphthalene. Quarterly Technical Progress Report |
| 作者: | Buchholz, B. A.
|
| 出版年: | 2016
|
| 发表日期: | 2016-02-05
|
| 总页数: | 6
|
| 国家: | 美国
|
| 语种: | 英语
|
| 英文摘要: | The project has two main goals: 1) Identify the types of adducts naphthalene (NA) forms with DNA and 2) determine whether adduct formation correlates with site selective tumor formation in defined subcompartments of the respiratory tract (respiratory and olfactory nasal epithelium and airways of mice, rats and rhesus monkeys). Five tasks are associated with the completion of the goals. Task 1: Contracting and Animal Use Approvals. IACUC and ACURO approvals are complete. The subcontract with UC Davis (UCD) was executed in December 2014. Task 2: Perform In Vitro Study for Goal 1. Rat and mouse samples exposures completed. Monkey samples need to be exposed in next quarter. Task 3: Perform In Vitro Study for Goal 2. Mouse and rat ex vivo exposures completed. Monkey samples need to be completed in the next quarter. Task 4: Sample Preparation and Analysis. Mouse and Rat Goal 2 samples completed. Monkey samples remain to be done for Goal 2. Rat samples completed for Goal 1. Mouse and Monkey samples for Goal 1 need to be completed. Task 5: Data Interpretation and Reporting. Poster will be presented at 2016 Society of Toxicology Meeting. Outline for paper on adduct formation complete and similar to poster for SOT meeting. |
| URL: | http://www.osti.gov/scitech/servlets/purl/1239176
|
| Citation statistics: |
|
| 资源类型: | 研究报告
|
| 标识符: | http://119.78.100.158/handle/2HF3EXSE/42276
|
| Appears in Collections: | 过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响
|
| File Name/ File Size |
Content Type |
Version |
Access |
License |
|
|---|
| 1239176.pdf（219KB） | 研究报告 | -- | 开放获取 | | View
Download
|
|
| Recommended Citation: | |
Buchholz, B. A.. Mechanism for Clastogenic Activity of Naphthalene. Quarterly Technical Progress Report. 2016-01-01.
|
|
|