DOI: 10.1016/j.jcou.2016.12.007
Scopus记录号: 2-s2.0-85007398034
论文题名: Processing of ketoconazole-4-aminobenzoic acid cocrystals using dense CO2 as an antisolvent
作者: Kotbantao G. ; Charoenchaitrakool M.
刊名: Journal of CO2 Utilization
ISSN: 22129820
出版年: 2017
卷: 17 语种: 英语
英文关键词: 4-amino benzoic acid
; Cocrystal
; Crystallization
; Gas
; Ketoconazole
Scopus关键词: Acetone
; Amino acids
; Benzoic acid
; Carbon
; Carbon dioxide
; Crystallization
; Dissolution
; Ethanol
; Gallium
; Gases
; Methanol
; Mixtures
; Solvents
; Aminobenzoic acid
; Co-crystals
; Cocrystallization
; Dissolution rates
; Ketoconazole
; Physical mixtures
; Slow evaporation
; Solvent mixtures
; Organic solvents
英文摘要: Graphical abstract: The aim of this work was to improve the dissolution rate of a poorly water-soluble antifungal drug, ketoconazole (KET), by forming cocrystal with 4-amino benzoic acid (PABA). Gas Anti-Solvent (GAS) technique with the use of dense carbon dioxide as an anti-solvent was applied for cocrystallization. The effects of KET to PABA molar ratio (1:2, 1:1 and 1:0.5), temperature (25-45°C) and solvent type (methanol, ethanol, acetone and a solvent mixture of methanol and ethanol) on drug content and dissolution rate were investigated. It was found that the drug content of the produced cocrystal via GAS was approximately 77%, which was equivalent to 1:1 molar ratio, irrespective of the drug to coformer molar ratio used at the starting. Cocrystal synthesized by GAS using KET to PABA molar ratio of 1:2 in methanol at 25°C exhibited the fastest dissolution rate compared to unprocessed drug, physical mixture and cocrystal prepared by slow evaporation. © 2016 Elsevier Ltd. 资助项目: Kasetsart University
; Kasetsart University Research and Development Institute
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/52824
Appears in Collections: 影响、适应和脆弱性
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Recommended Citation:
Kotbantao G.,Charoenchaitrakool M.. Processing of ketoconazole-4-aminobenzoic acid cocrystals using dense CO2 as an antisolvent[J]. Journal of CO2 Utilization,2017-01-01,17