| DOI: | 10.1016/j.jcou.2013.09.001
|
| Scopus记录号: | 2-s2.0-84889094562
|
| 论文题名: | Supercritical anti-solvent (SAS) micronization of Manilkara kauki bioactive fraction (DLBS2347) |
| 作者: | Widjojokusumo E.; Veriansyah B.; Tjandrawinata R.R.
|
| 刊名: | Journal of CO2 Utilization
|
| ISSN: | 22129820
|
| 出版年: | 2013
|
| 卷: | 2017-03-04 | | 起始页码: | 30
|
| 结束页码: | 36
|
| 语种: | 英语
|
| 英文关键词: | Anti solvent
; Herbal drug
; Manilkara kauki (DLBS2347)
; Micronization
; Precipitation
; Supercritical carbon dioxide
|
| Scopus关键词: | Anti-solvents
; Herbal drug
; Manilkara kauki (DLBS2347)
; Micronizations
; Supercritical carbon dioxides
; Acetone
; Dimethyl sulfoxide
; Precipitation (chemical)
; Solvents
; Supercritical fluid extraction
; Carbon dioxide
; Manilkara
; Manilkara kauki
|
| 英文摘要: | Application of supercritical carbon dioxide in particle modification showed promising results due to less toxic solvent used and its relatively easy alteration on particle characteristic. Unfortunately, the use of this technology in herbal drugs or extracts is still limited. This research studied a new approach of herbal drugs processing technology. The micronization of Manilkara kauki L. Dubard's leaf extract (DLBS2347) using supercritical anti-solvent (SAS) was conducted with carbon dioxide as anti-solvent. Experiment results showed that type of solvents, pressure, temperature and carbon dioxide (CO2) mol fraction influenced its morphology and active compound concentration. Polar solvent such as dimethyl sulfoxide, methanol and ethanol produced sticky particle due to hygroscopic nature of simple carbohydrate that present in the product. Acetone precipitation of DLBS2347 has the highest active compound concentration. Lower pressure, temperature and CO2 mol fraction resulted small particle size (<1 μm) of DLBS2347. In addition, precipitation of active compound is mainly affected by pressure that correlated to extract impurities. Taken together, optimum condition for micronizing DLBS2347 using SAS with acetone solution was at 40 C, 15 MPa and 0.95 mol fraction CO2. © 2013 Elsevier Ltd. All rights reserved. |
| Citation statistics: |
|
| 资源类型: | 期刊论文
|
| 标识符: | http://119.78.100.158/handle/2HF3EXSE/53048
|
| Appears in Collections: | 影响、适应和脆弱性
|
|
There are no files associated with this item.
|
| Recommended Citation: | |
Widjojokusumo E.,Veriansyah B.,Tjandrawinata R.R.. Supercritical anti-solvent (SAS) micronization of Manilkara kauki bioactive fraction (DLBS2347)[J]. Journal of CO2 Utilization,2013-01-01,2017-03-04
|
|
|