| DOI: | 10.1016/j.tree.2015.07.009
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| 论文题名: | Multigene Family Evolution: Perspectives from Insect Chemoreceptors |
| 作者: | Benton R.
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| 刊名: | Trends in Ecology and Evolution
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| ISSN: | 1695347
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| 出版年: | 2015
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| 卷: | 30, 期:10 | | 起始页码: | 590
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| 结束页码: | 600
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| 语种: | 英语
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| Scopus关键词: | chemoreception
; coevolution
; divergence
; ecological modeling
; gene expression
; genome
; homology
; insect
; ligand
; pheromone
; plant
; protein
; selection
; signaling
; temperature effect
; Animalia
; Hexapoda
; cell surface receptor
; ligand
; olfactory receptor
; adaptation
; animal
; channel gating
; genetics
; insect
; molecular evolution
; multigene family
; olfactory receptor
; phylogeny
; Adaptation, Physiological
; Animals
; Evolution, Molecular
; Insects
; Ion Channel Gating
; Ligands
; Multigene Family
; Phylogeny
; Receptors, Cell Surface
; Receptors, Odorant
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| 英文摘要: | Understanding the birth and diversification of multigene families is a fundamental evolutionary problem. I argue for the insect chemoreceptor superfamily as an outstanding model. Although these receptors are currently the preserve of neuroscientists, putative homologous genes exist in diverse animal and plant genomes, implying an ancient origin. Moreover, functional studies suggest that they act as ligand-gated ion channels in both chemosensory and non-chemosensory processes. This family permits synergism of investigations into its structural and regulatory evolution with ecological studies of the selective pressures driving these changes. In addition, sequence divergence in these receptors can be exploited through co-evolutionary and comparative genomics analyses to help to elucidate their 3D structure and signaling mechanisms, and to reveal experimentally-accessible candidate loci to explore the genetic basis of adaptation. The insect chemoreceptor multigene family might have originated in the ancestor of animals and plants, and is thought to encode an unusual class of heptahelical ion channels. In addition to wide-ranging functions in detection of environmental chemicals and pheromones, emerging data implicate particular family members in thermosensation and photoreception, as well as in non-sensory roles. The superfamily illustrates how both regulatory and structural evolution are involved in diversifying the expression and function of members of a multigene family. Protein sequence variation within the superfamily over long and short evolutionary timescales has been exploited to inform receptor structure and signaling mechanisms. © 2015 Elsevier Ltd. |
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| 资源类型: | 期刊论文
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/67127
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| Appears in Collections: | 全球变化的国际研究计划
气候变化与战略
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作者单位: | Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
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| Recommended Citation: | |
Benton R.. Multigene Family Evolution: Perspectives from Insect Chemoreceptors[J]. Trends in Ecology and Evolution,2015-01-01,30(10)
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