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DOI: 10.1016/j.tree.2015.03.009
论文题名:
Measurably evolving pathogens in the genomic era
作者: Biek R.; Pybus O.G.; Lloyd-Smith J.O.; Didelot X.
刊名: Trends in Ecology and Evolution
ISSN: 1695347
出版年: 2015
卷: 30, 期:6
起始页码: 306
结束页码: 313
语种: 英语
英文关键词: Bacteria ; DNA virus ; Epidemiological models ; Evolutionary rate ; Infectious disease ; Phylodynamics
Scopus关键词: bacterium ; comparative study ; epidemiology ; genetic variation ; genome ; genomics ; infectious disease ; RNA ; sampling ; virus ; DNA viruses ; RNA viruses ; bacterial genome ; bacterium ; genetics ; molecular evolution ; mutation rate ; population dynamics ; RNA virus ; virus genome ; Bacteria ; Evolution, Molecular ; Genome, Bacterial ; Genome, Viral ; Mutation Rate ; Population Dynamics ; RNA Viruses
英文摘要: Current sequencing technologies have created unprecedented opportunities for studying microbial populations. For pathogens with comparatively low per-site mutation rates, such as DNA viruses and bacteria, whole-genome sequencing can reveal the accumulation of novel genetic variation between population samples taken at different times. The concept of 'measurably evolving populations' and related analytical approaches have provided powerful insights for fast-evolving RNA viruses, but their application to other pathogens is still in its infancy. We argue that previous distinctions between slow- and fast-evolving pathogens become blurred once evolution is assessed at a genome-wide scale, and we highlight important analytical challenges to be overcome to infer pathogen population dynamics from genomic data. © 2015 Elsevier Ltd.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/67148
Appears in Collections:全球变化的国际研究计划
气候变化与战略

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作者单位: Boyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom; Fogarty International Center, National Institutes of Health, Bethesda, United States; Department of Zoology, University of Oxford, Oxford, United Kingdom; Department of Ecology and Evolutionary Biology, University of California at Los Angeles, Los Angeles, CA, United States; Department of Infectious Disease Epidemiology, Imperial College, London, United Kingdom

Recommended Citation:
Biek R.,Pybus O.G.,Lloyd-Smith J.O.,et al. Measurably evolving pathogens in the genomic era[J]. Trends in Ecology and Evolution,2015-01-01,30(6)
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