| DOI: | 10.1016/j.tree.2015.02.009
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| 论文题名: | Adaptive virulence evolution: The good old fitness-based approach |
| 作者: | Alizon S.; Michalakis Y.
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| 刊名: | Trends in Ecology and Evolution
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| ISSN: | 1695347
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| 出版年: | 2015
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| 卷: | 30, 期:5 | | 起始页码: | 248
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| 结束页码: | 254
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| 语种: | 英语
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| 英文关键词: | Epidemiology
; Evolution
; Fitness
; Pathogen
; Trade-off
; Virulence
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| Scopus关键词: | adaptation
; disease transmission
; infectious disease
; life cycle
; virulence
; adaptation
; animal
; bacterium
; disease transmission
; evolution
; genetics
; host pathogen interaction
; life cycle stage
; parasite
; pathogenicity
; reproductive fitness
; virulence
; virus
; Adaptation, Physiological
; Animals
; Bacteria
; Biological Evolution
; Disease Transmission, Infectious
; Genetic Fitness
; Host-Pathogen Interactions
; Life Cycle Stages
; Parasites
; Virulence
; Viruses
|
| 英文摘要: | Infectious diseases could be expected to evolve towards complete avirulence to their hosts if given enough time. However, this is not the case. Often, virulence is maintained because it is linked to adaptive advantages to the parasite, a situation that is often associated with the hypothesis known as the transmission-virulence trade-off hypothesis. Here, we argue that this hypothesis has three limitations, which are related to how virulence is defined, the possibility of multiple trade-offs, and the difficulty of testing the hypothesis empirically. By adopting a fitness-based approach, where the relation between virulence and the fitness of the parasite throughout its life cycle is directly assessed, it is possible to address these limitations and to determine directly whether virulence is adaptive. © 2015 Elsevier Ltd. |
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| 资源类型: | 期刊论文
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/67228
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| Appears in Collections: | 全球变化的国际研究计划
气候变化与战略
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作者单位: | Laboratoire MIVEGEC (UMR CNRS 5290, IRD 224, UM), 911 Avenue Agropolis, BP 64501, Montpellier Cedex 5, France
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| Recommended Citation: | |
Alizon S.,Michalakis Y.. Adaptive virulence evolution: The good old fitness-based approach[J]. Trends in Ecology and Evolution,2015-01-01,30(5)
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