DOI: 10.1016/j.tree.2012.10.020
论文题名: Complex cocktails: The evolutionary novelty of venoms
作者: Casewell N.R. ; Wüster W. ; Vonk F.J. ; Harrison R.A. ; Fry B.G.
刊名: Trends in Ecology and Evolution
ISSN: 1695347
出版年: 2013
卷: 28, 期: 4 起始页码: 219
结束页码: 229
语种: 英语
英文关键词: Antivenom
; Convergence
; Drug discovery
; Evolution
; Gene duplication
; Selection
; Venom
Scopus关键词: venom
; animal
; chemical composition
; data acquisition
; drug development
; evolutionary biology
; genetic variation
; numerical model
; venom
; animal
; chemistry
; competitive behavior
; evolution
; food chain
; genetics
; molecular evolution
; predation
; review
; sequence analysis
; sequence homology
; Animals
; Biological Evolution
; Competitive Behavior
; Evolution, Molecular
; Food Chain
; Predatory Behavior
; Sequence Analysis, Protein
; Sequence Homology
; Venoms
; Animalia
英文摘要: Venoms have evolved on numerous occasions throughout the animal kingdom. These 'biochemical weapon systems' typically function to facilitate, or protect the producing animal from, predation. Most venomous animals remain unstudied despite venoms providing model systems for investigating predator-prey interactions, molecular evolution, functional convergence, and novel targets for pharmaceutical discovery. Through advances in 'omic' technologies, venom composition data have recently become available for several venomous lineages, revealing considerable complexity in the processes responsible for generating the genetic and functional diversity observed in many venoms. Here, we review these recent advances and highlight the ecological and evolutionary novelty of venom systems. © 2012 Elsevier Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/67435
Appears in Collections: 全球变化的国际研究计划 气候变化与战略
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作者单位: Molecular Ecology and Evolution Group, School of Biological Sciences, Bangor University, Bangor, LL57 2UW, United Kingdom; Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, United Kingdom; Naturalis Biodiversity Center, Darwinweg 2, 2333CR, Leiden, Netherlands; Venom Evolution Laboratory, School of Biological Sciences, University of Queensland, Qld 4072, Australia
Recommended Citation:
Casewell N.R.,Wüster W.,Vonk F.J.,et al. Complex cocktails: The evolutionary novelty of venoms[J]. Trends in Ecology and Evolution,2013-01-01,28(4)