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The presence of evaporate and incompetent formations (i.e., decollement horizons) within the sedimentary sequence of fold-thrust belts can control their structural style and deformation evolution. In the present study, the influence of the decollement layers (e.g., basal and internal decollement layers) on the deformation style of several segments of the Zagros Fold-Thrust Belt (ZFTB), SW Iran (e.g., Fars Arc, Dezful Embayment, and Izeh Zone) was investigated using a series of analogue models of accretionary wedges. The study of seismic profiles to understand the structural evolution of these segments of the belt, where several decollement intervals acted as basal and internal decollements, is complemented by the analogue model results. The experimental results reveal that the thickness of the internal decollement layers influences the creation of fold-dominated or thrust-dominated deformations, respectively. Experimental models and seismic data highlight that incompetent layers act as barrier units against fault propagation (in-sequence and/or out-of-sequence faults) into overlying strata towards southwest by fore-deformation and control the rate of deformation propagation in the ZFTB. The presence of both the basal and internal decollement layers located at different stratigraphic levels is required to form disharmonic decollement folds in the foreland of the ZFTB. In addition, the geometry, spacing, activity, and propagation of faults as well as the topographic height of the critical wedges are directly controlled by low-frictional decollements (Geophys J Int, 165(1):336–356 2006; Geochem Geophys Geosyst, 14:1131–1155 2013). The seismic profiles of the ZFTB showed that in addition to lithological contrasts, the existence and activity of deep-seated and basement faults had a big impact on the structural styles of the region. © 2017, Springer-Verlag Berlin Heidelberg.