DOI: 10.1016/j.atmosenv.2014.04.047
Scopus记录号: 2-s2.0-84899844533
论文题名: Characteristics of trace metals in fine (PM2.5) and inhalable (PM10) particles and its health risk assessment along with in-silico approach in indoor environment of India
作者: Satsangi P ; G ; , Yadav S ; , Pipal A ; S ; , Kumbhar N
刊名: Atmospheric Environment
ISSN: 0168-2563
EISSN: 1573-515X
出版年: 2014
卷: 92 起始页码: 384
结束页码: 393
语种: 英语
英文关键词: Health risk assessment
; IAQ
; In-silico study
; Metal toxicity
; PM concentration
; Trace metals
Scopus关键词: Acetylation
; Aerodynamics
; Atomic emission spectroscopy
; Cadmium
; Health risks
; Hydrogen bonds
; Lead
; Metals
; Nickel
; Proteins
; Risk assessment
; IAQ
; In-silico
; Metal toxicity
; Pm concentrations
; Trace metal
; Copper
; antimony
; cadmium
; calcium
; chromium
; cobalt
; coordination compound
; copper
; ferrous ion
; histone
; lead
; manganese
; nickel
; sodium
; trace metal
; zinc
; ambient air
; article
; cancer risk
; computer model
; concentration (parameters)
; deacetylation
; DNA methylation
; health hazard
; hydrogen bond
; India
; microenvironment
; particulate matter
; priority journal
; risk assessment
; rural area
; ubiquitination
; urban area
Scopus学科分类: Environmental Science: Water Science and Technology
; Earth and Planetary Sciences: Earth-Surface Processes
; Environmental Science: Environmental Chemistry
英文摘要: Indoor concentrations of fine (PM2.5: aerodynamic diameter≤2.5) and inhalable (PM10: aerodynamic diameter≤10μm) particles and its associated toxic metals are of concern now-a-days due to its effects on human health and environment. PM10 and PM2.5 samples were collected from indoor microenvironments on glass fiber and PTFE filter paper using low volume air sampler in Pune. The average concentration of PM2.5 and PM10 were 89.7±43.2μgm-3 and 138.2±68.2μgm-3 at urban site while it was 197.5±84.3 and 287±92μgm-3 at rural site. Trace metals such as Cd, Co, Cr, Cu, Fe, Mn, Pb, Sb and Zn in particulate matter were estimated by ICP-AES. Concentrations of crustal metals were found to be higher than the carcinogenic metals in both the microenvironments. On the contrary the soluble and bio-availability fraction of carcinogenic metals were found higher thus it may cause the higher risk to human health. Therefore, cancer risk assessment of carcinogenic metals; Cr, Ni and Cd was calculated. Among the carcinogenic metals, Ni showed highest cancer risk in indoor PM. The higher cancer risk assessment of Ni has been supported by In-silico study which suggested that Ni actively formed co-ordination complex with histone proteins (i.e. H3-Ni/H4-Ni) by maintaining strong hydrogen bonding interactions with Asp and Glu residues of nucleosomal proteins. Present In-silico study of Ni-histone complexes will help to emphasize the possible role of Asp and Glu residues in DNA methylation, deacetylation and ubiquitinations of nucleosomal proteins. Hence, this study could pave the way to understand the structural consequence of Ni in nucleosomal proteins and its impact on epigenetic changes which ultimately cause lung and nasal cancer. © 2014 Elsevier Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/80834
Appears in Collections: 气候变化事实与影响
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作者单位: Department of Chemistry, University of Pune, Pune 411 007, India; Institute of Bioinformatics and Biotechnology, University of Pune, Pune 411 007, India
Recommended Citation:
Satsangi P,G,, Yadav S,et al. Characteristics of trace metals in fine (PM2.5) and inhalable (PM10) particles and its health risk assessment along with in-silico approach in indoor environment of India[J]. Atmospheric Environment,2014-01-01,92