DOI: 10.1016/j.atmosenv.2015.08.092
Scopus记录号: 2-s2.0-84941139909
论文题名: Exposure to volatile organic compounds and associated health risks in windsor, Canada
作者: Khanchi A ; , Hebbern C ; A ; , Zhu J ; , Cakmak S
刊名: Atmospheric Environment
ISSN: 0168-2563
EISSN: 1573-515X
出版年: 2015
卷: 120 起始页码: 152
结束页码: 159
语种: 英语
英文关键词: Excess cancer risk
; Inhalation unit risk
; Personal exposure
; Tumorigenic dose
; Volatile organic compound
Scopus关键词: Diseases
; Gas chromatography
; Health
; Organic compounds
; Risk assessment
; Risk perception
; Volatile organic compounds
; Adverse health effects
; Cancer risk
; Negative correlation
; Non-cancer risk assessments
; Outdoor concentrations
; Personal exposures
; Reference concentration
; Tumorigenic dose
; Health risks
; 1,3 butadiene
; 1,4 dichlorobenzene
; acetaldehyde
; benzene
; bromodichloromethane
; carbon tetrachloride
; chloroform
; dichloromethane
; ethylbenzene
; isoprene
; naphthalene
; styrene
; tetrachloroethylene
; volatile organic compound
; adult
; cancer
; concentration (composition)
; dose-response relationship
; health risk
; indoor air
; pollution exposure
; risk assessment
; smoking
; tumor
; volatile organic compound
; arithmetic
; Article
; Canada
; cancer risk
; environmental exposure
; human
; ion monitoring
; occupational exposure
; personal monitoring
; priority journal
; seasonal variation
; statistical significance
; Canada
Scopus学科分类: Environmental Science: Water Science and Technology
; Earth and Planetary Sciences: Earth-Surface Processes
; Environmental Science: Environmental Chemistry
英文摘要: Objective: We examined relationships among measurements of volatile organic compounds (VOCs) and performed cancer and non-cancer risk assessments to determine potential adverse health effects. Methods: Personal, indoor and outdoor concentrations of VOCs were measured for 50 non-smoking adults in Windsor, Ontario during winter and summer 2005. The potential excess cancer cases associated with personal concentration were estimated by the Inhalation Unit Risk (USEPA IRIS) and Tumorigenic Concentration (Health Canada). Inhalation Reference Concentration (RfC) was used to evaluate non-cancer adverse effects. Indoor and personal concentrations were statistically compared. Correlations of personal concentrations were estimated to investigate the associations among VOCs. Results: Estimated median lifetime excess cancer risks (95th percentile upper-bound) of benzene and 1,3-butadiene were 8.09 and 4.77 per 1 million. Acetaldehyde presented the highest non-cancer risk. For some VOCs, the personal and indoor geometric means were similar, but arithmetic personal means were higher than the arithmetic indoor means (p < 0.05). Negative correlations among personal VOC concentrations were not sizable. Conclusion: Evaluation of potential cancer and non-cancer risks from VOCs at the personal level should not rely merely on ambient (indoor and outdoor) VOC concentrations. Our analysis showed that personal risk had a complicated pattern that needs further investigation. Our results can be used to prioritize mitigation strategies to protect human health. © 2015. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/81465
Appears in Collections: 气候变化事实与影响
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作者单位: Population Studies Division, Environmental Health Science and Research Bureau Health Canada, 50 Columbine Driveway, Ottawa, ON, Canada; Exposure and Biomonitoring Division Health Canada, 50 Columbine Driveway, Ottawa, ON, Canada
Recommended Citation:
Khanchi A,, Hebbern C,A,et al. Exposure to volatile organic compounds and associated health risks in windsor, Canada[J]. Atmospheric Environment,2015-01-01,120