globalchange  > 气候变化事实与影响
DOI: 10.1016/j.atmosenv.2015.03.017
Scopus记录号: 2-s2.0-84924589588
论文题名:
Inhibition of the WNT/β-catenin pathway by fine particulate matter in haze: Roles of metals and polycyclic aromatic hydrocarbons
作者: Lee K; -Y; , Cao J; -J; , Lee C; -H; , Hsiao T; -C; , Yeh C; -T; , Huynh T; -T; , Han Y; -M; , Li X; -D; , Chuang K; -J; , Tian L; , Ho K; -F; , Chuang H; -C
刊名: Atmospheric Environment
ISSN: 0168-2563
EISSN: 1573-515X
出版年: 2015
卷: 109
起始页码: 118
结束页码: 129
语种: 英语
英文关键词: Air pollution ; Apoptosis ; Metal ; Particulate matter ; Polycyclic aromatic hydrocarbons ; β-catenin
Scopus关键词: Air pollution ; Aromatic compounds ; Aromatization ; Cell death ; Hydrocarbons ; Metals ; Pathology ; Pollution ; Pollution control ; Polycyclic aromatic hydrocarbons ; Biological pathways ; Catenin signaling ; Fine particulate matter ; Hong-kong ; Mouse lung ; Particulate Matter ; Physico-chemical characterization ; Proteomic profiling ; Aromatic hydrocarbons ; aluminum ; beta catenin ; cadmium ; caspase 3 ; cesium ; chromium ; cobalt ; copper ; cyclin D1 ; gamma interferon ; interleukin 6 ; iron ; lead ; manganese ; metal ; molybdenum ; nickel ; polycyclic aromatic hydrocarbon ; selenium ; strontium ; t cell transcription factor 4 ; titanium ; transcription factor ; tumor necrosis factor alpha ; unclassified drug ; vanadium ; Wnt protein ; zinc ; apoptosis ; atmospheric pollution ; enzyme activity ; gene expression ; haze ; inhibition ; PAH ; particulate matter ; physicochemical property ; protein ; proteomics ; rodent ; signaling ; air pollutant ; airborne particle ; animal experiment ; animal model ; animal tissue ; apoptosis ; Article ; cell viability ; China ; controlled study ; cytokine production ; female ; functional proteomics ; haze ; Hong Kong ; human ; human cell ; in vitro study ; lung ; lung alveolus ; lung parenchyma ; lung toxicity ; meteorology ; mouse ; nonhuman ; particle size ; particulate matter ; physical chemistry ; pneumonia ; priority journal ; Wnt signaling pathway ; Beijing [China] ; China ; Hong Kong ; Shaanxi ; Xian
Scopus学科分类: Environmental Science: Water Science and Technology ; Earth and Planetary Sciences: Earth-Surface Processes ; Environmental Science: Environmental Chemistry
英文摘要: Air pollution might have a great impact on pulmonary health, but biological evidence in response to particulate matter less than 2.5μm in size (PM2.5) has been lacking. Physicochemical characterization of haze PM2.5 collected from Beijing, Xian and Hong Kong was performed. Biological pathways were identified by proteomic profiling in mouse lungs, suggesting that WNT/β-catenin is important in the response to haze PM2.5. Suppression of β-catenin levels, activation of caspase-3 and alveolar destruction, as well as IL-6, TNF-α and IFN-γ production, were observed in the lungs. The inhibition of β-catenin, TCF4 and cyclin D1 was observed invitro in response to haze PM2.5. The inhibition of WNT/β-catenin signaling, apoptosis-related results (caspase-3 and alveolar destruction), and inflammation, particularly including caspase-3 and alveolar destruction, were more highly associated with polycyclic aromatic hydrocarbons in haze PM2.5. In conclusion, decreased WNT/β-catenin expression modulated by haze PM2.5 could be involved in alveolar destruction and inflammation during haze episodes. © 2015 Elsevier Ltd.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/81812
Appears in Collections:气候变化事实与影响

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作者单位: Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Key Laboratory of Aerosol, SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an, China; Department of Pathology, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Environmental Engineering, National Central University, Taoyuan, Taiwan; Cancer Center, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of the Civil and Environmental Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong; Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan; School of Public Health, The University of Hong Kong, Hong Kong SAR, China; Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong; Shenzhen Municipal Key Laboratory for Health Risk Analysis, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan

Recommended Citation:
Lee K,-Y,, Cao J,et al. Inhibition of the WNT/β-catenin pathway by fine particulate matter in haze: Roles of metals and polycyclic aromatic hydrocarbons[J]. Atmospheric Environment,2015-01-01,109
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