DOI: 10.1016/j.atmosenv.2017.08.061
Scopus记录号: 2-s2.0-85028537097
论文题名: Histological changes in lung tissues related with sub-chronic exposure to ambient urban levels of PM2.5 in Córdoba, Argentina
作者: Tavera Busso I ; , Vera A ; , Mateos A ; C ; , Amarillo A ; C ; , Carreras H
刊名: Atmospheric Environment
ISSN: 0168-2563
EISSN: 1573-515X
出版年: 2017
卷: 167 起始页码: 616
结束页码: 624
语种: 英语
英文关键词: Comet assay
; Elemental composition
; Lung histology
; PAHs
; PM2.5
Scopus关键词: Biological organs
; Chemical analysis
; Histology
; Polycyclic aromatic hydrocarbons
; Tissue
; Chemical compositions
; Comet assays
; Elemental compositions
; Environmental parameter
; Fine particulate matter (PM2.5)
; Histological analysis
; Histological changes
; PM2.5
; Particles (particulate matter)
; arsenic
; cadmium
; chromium
; cuprous ion
; lead
; mercury
; nickel
; titanium
; zinc ion
; ambient air
; bioassay
; biochemical composition
; cells and cell components
; health impact
; histology
; PAH
; particulate matter
; pollution exposure
; respiratory disease
; rodent
; urban pollution
; ambient air
; animal tissue
; Argentina
; Article
; chemical composition
; controlled study
; DNA fragmentation
; gas
; genotoxicity
; histology
; long term exposure
; lower respiratory tract
; lung
; lung alveolus macrophage
; lung parenchyma
; mass spectrometry
; nonhuman
; particulate matter
; priority journal
; rat
; thoracic cavity
; urban area
; Argentina
; Cordoba [Argentina]
; Animalia
; Rattus norvegicus
Scopus学科分类: Environmental Science: Water Science and Technology
; Earth and Planetary Sciences: Earth-Surface Processes
; Environmental Science: Environmental Chemistry
英文摘要: Concentration of fine particulate matter (PM2.5) is one of the most important environmental parameters to estimate health impacts attributable to air pollution. Despite the fact there are many studies regarding PM2.5 effects on human health, most of them were performed under conditions that do not simulate the natural particles interaction with the organism. In the present paper, we studied the effects of mammals’ sub-chronic exposure to PM2.5 on the lower respiratory tract, addressing realistic exposure conditions to normal urban air. Thus, we exposed Wistar rats under controlled settings to the same normal urban air, with and without particles. Next, we analyzed chemical composition of PM2.5 and lungs samples, performed a histologic examination and run the comet assay to assess genotoxic effects. We found a strong agreement between lung tissues and PM2.5 elemental composition suggesting that metals found in lungs came from the particles inhaled. Histological analysis showed a mild to moderate infiltration, with a reduction of alveoli lumen and increment of alveolar macrophages and periodic acid-Schiff (PAS) (+) cells in treated animals. We also observed an increase in the number of nuclei with comets, mostly comets type 3, with a high DNA fragmentation as well. These results provide strong evidence that sub-chronic exposure to low particle levels, even below the 24 h WHO standard, can cause injuries in lungs tissues and DNA damage, as well. © 2017 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/82631
Appears in Collections: 气候变化事实与影响
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作者单位: Instituto Multidisciplinario de Biología Vegetal (IMBIV), CONICET and Departamento de Química, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, Argentina; Fundación “J. Robert Cade”, Córdoba, Argentina
Recommended Citation:
Tavera Busso I,, Vera A,, Mateos A,et al. Histological changes in lung tissues related with sub-chronic exposure to ambient urban levels of PM2.5 in Córdoba, Argentina[J]. Atmospheric Environment,2017-01-01,167