globalchange  > 气候减缓与适应
DOI: 10.1007/s10584-015-1421-3
Scopus记录号: 2-s2.0-84940725360
论文题名:
Historical and experimental evidence for enhanced concentration of artemesinin, a global anti-malarial treatment, with recent and projected increases in atmospheric carbon dioxide
作者: Zhu C.; Zeng Q.; McMichael A.; Ebi K.L.; Ni K.; Khan A.S.; Zhu J.; Liu G.; Zhang X.; Cheng L.; Ziska L.H.
刊名: Climatic Change
ISSN: 0165-0009
EISSN: 1573-1480
出版年: 2015
卷: 132, 期:2
起始页码: 295
结束页码: 306
语种: 英语
Scopus关键词: Carbon ; Carbon dioxide ; Diseases ; Plants (botany) ; Atmospheric carbon dioxide ; Atmospheric carbon dioxide concentration ; Combination therapy ; Experimental evidence ; Foliar concentration ; Plasmodium falciparum ; Primary sources ; Scientific community ; Atmospheric chemistry ; annual plant ; atmospheric chemistry ; carbon dioxide ; concentration (composition) ; cultivation ; disease treatment ; drug ; malaria ; public health ; Africa ; China ; Artemisia annua ; Plasmodium falciparum
英文摘要: Although the role of rising atmospheric carbon dioxide concentration [CO2] on plant growth and fecundity is widely acknowledged as important within the scientific community; less research is available regarding the impact of [CO2] on secondary plant compounds, even though such compounds can play a significant role in human health. At present, Artemisia annua, an annual plant species native to China, is widely recognized as the primary source of artemesinin used in artemesinin combination therapies or ACTs. ACTs, in turn, are used globally for the treatment of simple Plasmodium falciparum malaria, the predominant form of malaria in Africa. In this study, artemesinin concentration was quantified for multiple A. annua populations in China using a free-air CO2 enrichment (FACE) system as a function of [CO2]-induced changes both in situ and as a function of the foliar ratio of carbon to nitrogen (C:N). The high correlation between artemesinin concentration and C:N allowed an historical examination of A. annua leaves collected at 236 locations throughout China from 1905 through 2009. Both the historical and experimental data indicate that increases in artemesinin foliar concentration are likely to continue in parallel with the ongoing increase in atmospheric [CO2]. The basis for the [CO2]-induced increase in artemesinin is unclear, but could be related to the carbon: nutrient hypothesis of Bryant et al. (1983). Overall, these data provide the first evidence that historic and projected increases in atmospheric [CO2] may be associated with global changes in artemesinin chemistry, potentially allowing a greater quantity of drug available for the same area of cultivation. © 2015, Springer Science+Business Media Dordrecht (outside the USA).
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/84527
Appears in Collections:气候减缓与适应
气候变化事实与影响

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作者单位: State Key Laboratory of Soil and Sustainable Agriculture, Chinese Academy of Sciences, East Beijing Road, Nanjing, China; Jiangsu Institute of Botany, Chinese Academy of Science, Nanjing Botanical Garden, Nanjing, China; College of Medicine, Biology and Environment, Australian National University, National Territory, Canberra, Australia; School of Public Health, University of Washington, Seattle, WA, United States; College of Public Health, University of Nebraska Medical Center, Omaha, NE, United States; The Herbarium, State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, 20 Nanxincun, Xiangshan, Beijing, China; College of Life Sciences, Zhejiang University, Hangzhou, China; USDA-ARS, Crop Systems and Global Change Lab, Beltsville, MD, United States

Recommended Citation:
Zhu C.,Zeng Q.,McMichael A.,et al. Historical and experimental evidence for enhanced concentration of artemesinin, a global anti-malarial treatment, with recent and projected increases in atmospheric carbon dioxide[J]. Climatic Change,2015-01-01,132(2)
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