DOI: 10.1016/j.marpolbul.2014.05.024
Scopus记录号: 2-s2.0-84906229379
论文题名: Comparative study of 17 β-estradiol on endocrine disruption and biotransformation in fingerlings and juveniles of Japanese sea bass Lateolabrax japonicus
作者: Thilagam H. ; Gopalakrishnan S. ; Bo J. ; Wang K.-J.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2014
卷: 85, 期: 2 起始页码: 332
结束页码: 337
语种: 英语
英文关键词: Cortisol
; EROD
; Estradiol
; Lateolabrax japonicus
; Serotonin
Scopus关键词: Bioconversion
; Brain
; Cortisol
; Fish
; Biotransformation system
; Endocrine disrupting chemicals
; EROD
; Estradiol
; Estrogenic contaminants
; Ethoxyresorufin-O-deethylase
; Lateolabrax japonicus
; Serotonin
; Endocrine disrupters
; acetylcholinesterase
; endocrine disruptor
; estradiol
; ethoxyresorufin deethylase
; hydrocortisone
; serotonin
; acetylcholinesterase
; cytochrome P450 1A1
; endocrine disruptor
; estradiol
; hydrocortisone
; serotonin
; water pollutant
; biotransformation
; endocrine disruptor
; enzyme activity
; fish
; sublethal effect
; animal experiment
; animal tissue
; article
; bass
; biotransformation
; body size
; brain level
; chemical analysis
; chemical interaction
; concentration response
; controlled study
; correlational study
; down regulation
; endocrine function
; environmental exposure
; feminization
; fingerling
; gill
; hydrocortisone blood level
; Japanese sea bass
; juvenile
; Lateolabrax japonicus
; LC 50
; long term exposure
; nonhuman
; sea pollution
; tissue distribution
; toxicity testing
; upregulation
; animal
; bass
; biotransformation
; blood
; brain
; comparative study
; drug effects
; endocrine system
; female
; growth, development and aging
; metabolism
; toxicity
; water pollutant
; Lateolabrax japonicus
; Serranidae
; Acetylcholinesterase
; Animals
; Bass
; Biotransformation
; Brain
; Cytochrome P-450 CYP1A1
; Endocrine Disruptors
; Endocrine System
; Estradiol
; Female
; Gills
; Hydrocortisone
; Serotonin
; Water Pollutants, Chemical
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: Estrogenic contaminants in the aquatic environment are associated with endocrine disruption and feminization in fish. The effects of endocrine disrupting chemicals (EDCs) on fish have been well documented. However, very few studies have focused on 17 β-estradiol (E2) and its effects on endocrine system and biotransformation in a single prolonged exposure. This study investigated changes in the levels of serotonin (5-hydroxytryptamine) and acetyl choline esterase (AchE) in brain, cortisol in plasma and Ethoxyresorufin-O-deethylase (EROD) activity in gill of two different size groups (fingerlings and juveniles) of Japanese sea bass (Lateolabrax japonicus) upon exposure to two sub-lethal concentrations (200 and 2000 ng L-1) of E2 for 30d. The results indicate that cortisol level and EROD activity significantly increased in both groups, whereas serotonin level increased in juveniles and decreased in fingerlings due to E2 exposure. The correlation analysis revealed that E2 significantly affected the endocrine and biotransformation systems in both age groups. © 2014 Elsevier Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/85332
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, Fujian 361005, China
Recommended Citation:
Thilagam H.,Gopalakrishnan S.,Bo J.,et al. Comparative study of 17 β-estradiol on endocrine disruption and biotransformation in fingerlings and juveniles of Japanese sea bass Lateolabrax japonicus[J]. Marine Pollution Bulletin,2014-01-01,85(2)