DOI: 10.1016/j.marpolbul.2014.01.025
Scopus记录号: 2-s2.0-84906216814
论文题名: Occurrence of xenobiotic ligands for retinoid X receptors and thyroid hormone receptors in the aquatic environment of Taiwan
作者: Chen C.-H. ; Chou P.-H. ; Kawanishi M. ; Yagi T.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2014
卷: 85, 期: 2 起始页码: 613
结束页码: 618
语种: 英语
英文关键词: Bioassays
; Retinoid X receptors
; River water
; Sediment
; Thyroid hormone receptors
Scopus关键词: Bioassay
; Endocrinology
; Hormones
; Rivers
; Sediments
; Transcription factors
; Water resources
; Aquatic environments
; Nuclear receptors
; Physiological functions
; Reporter gene assays
; Retinoid X receptor
; River water
; Synthetic compounds
; Thyroid hormone receptor
; Ligands
; retinoid X receptor
; river water
; thyroid hormone receptor
; xenobiotic agent
; endocrine disruptor
; ligand
; retinoid X receptor
; thyroid hormone receptor
; water pollutant
; xenobiotic agent
; bioassay
; fluvial deposit
; gene
; river water
; xenobiotics
; aquatic environment
; article
; bioassay
; environmental protection
; fractionation
; fungal gene
; high performance liquid chromatography
; reporter gene
; sediment
; Taiwan
; water analysis
; water pollution
; water sampling
; agonists
; analysis
; antagonists and inhibitors
; chemistry
; environmental monitoring
; genetic transfection
; genetics
; human
; isolation and purification
; metabolism
; procedures
; river
; toxicity
; water pollutant
; yeast
; Taiwan
; Biological Assay
; Endocrine Disruptors
; Environmental Monitoring
; Genes, Reporter
; Geologic Sediments
; Humans
; Ligands
; Receptors, Thyroid Hormone
; Retinoid X Receptors
; Rivers
; Taiwan
; Transfection
; Water Pollutants, Chemical
; Xenobiotics
; Yeasts
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: Various synthetic compounds are frequently discharged into the environment via human activities. Among them, certain contaminants may disrupt normal physiological functions of wildlife and humans via interactions with nuclear receptors. To protect human health and the environment, it is important to detect environmental ligands for human nuclear receptors. In this study, yeast-based reporter gene assays were used to investigate the occurrence of xenobiotic ligands for retinoid X receptors (RXR) and thyroid hormone receptors (TR) in the aquatic environment of Taiwan. Experimental results revealed that RXR agonist/antagonist activity was detected in river water and sediment samples. In particular, high RXR agonist/antagonist activity was found in the samples collected near river mouths. Additionally, few samples also elicited significant TR antagonist activity. Our findings show that the aquatic environment of Taiwan was contaminated with RXR and TR ligands. Further study is necessary to identify these xenobiotic RXR and TR agonists and antagonists. © 2014 Elsevier Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/85333
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: Department of Environmental Engineering, National Cheng Kung University, 1, University Road, Tainan City 70101, Taiwan; Graduate School of Science and Radiation Research Center, Osaka Prefecture University, 1-2 Gakuen-cho, Sakai, Osaka 599-8570, Japan
Recommended Citation:
Chen C.-H.,Chou P.-H.,Kawanishi M.,et al. Occurrence of xenobiotic ligands for retinoid X receptors and thyroid hormone receptors in the aquatic environment of Taiwan[J]. Marine Pollution Bulletin,2014-01-01,85(2)