DOI: 10.1016/j.marpolbul.2014.10.035
Scopus记录号: 2-s2.0-84913529386
论文题名: Transcriptomic response to estrogen exposure in the male Zhikong scallop, Chlamys farreri
作者: An L.-H. ; Zheng B.-H. ; Liu R.-Z. ; Fan Q. ; Wang Q.-K. ; Luo Y.-F.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2014
卷: 89, 期: 2018-01-02 起始页码: 59
结束页码: 66
语种: 英语
英文关键词: 454 Sequencing
; Estrogen
; Mechanism
; Transcriptome
; Zhikong scallop Chlamys farreri
Scopus关键词: Database systems
; Genes
; Mechanisms
; Molluscs
; Nucleic acids
; Proteins
; 454 Sequencing
; Biological pathways
; Biological process
; Cellular components
; Estrogen
; Molecular function
; Scallop chlamys
; Transcriptomes
; Shellfish
; estrogen
; estradiol
; estrogen
; transcriptome
; bivalve
; database
; estrogenic compound
; genotoxicity
; marine pollution
; pollution effect
; pollution exposure
; animal tissue
; Article
; bioaccumulation
; Chlamys farreri
; controlled study
; down regulation
; exocrine gland
; gene
; gene expression
; gene identification
; gene mapping
; gene sequence
; genetic database
; high throughput sequencing
; information processing
; male
; nonhuman
; risk assessment
; testis
; toxicogenetics
; transcriptomics
; upregulation
; animal
; drug effects
; gene expression profiling
; genetics
; scallop
; Chlamys farreri
; Animals
; Estradiol
; Estrogens
; Gene Expression Profiling
; Male
; Pectinidae
; Transcriptome
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: The transcriptomes of Zhikong scallop exposed to 17β-estradiol were determined using the Roche/454. A total of 51,997 unigenes, representing 45,030 contigs and 6967 singlets were obtained. And 14,028, 19,798 and 14,981 of these unigenes were annotated from the non-redundant nucleic acid database, non-redundant protein database and Swiss protein database, respectively. A total of 10,699 unigenes were further annotated to biological processes (9080), molecular functions (8692) and cellular components (7829) using the GO, and 8945 unigenes were mapped to biological pathways including the metabolism (2862) and genetic information processing (2263). Most importantly, 16,692 unigenes and 18,686 unigenes in testis, and 10,492 unigenes and 13,186 unigenes in digestive gland were up-regulated significantly after exposure to 50 and 500ngE2 /L; while 10,212 unigenes and 9409 unigenes in testis and 10,629 unigenes and 9463 unigenes in digestive gland were down-regulated. These valuable information provides insights into the mechanisms in invertebrate exposure to EDCs. © 2014 Elsevier Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/85714
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: State Environmental Protection Key Laboratory of Estuarine and Coastal Research, Chinese Research Academy of Environmental Sciences, Beijing, China; Tianjin Agricultural College, Tianjin, China; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
Recommended Citation:
An L.-H.,Zheng B.-H.,Liu R.-Z.,et al. Transcriptomic response to estrogen exposure in the male Zhikong scallop, Chlamys farreri[J]. Marine Pollution Bulletin,2014-01-01,89(2018-01-02)