globalchange  > 过去全球变化的重建
DOI: 10.1016/j.marpolbul.2015.03.039
Scopus记录号: 2-s2.0-84930761552
论文题名:
Assessment of growth, genotoxic responses and expression of stress related genes in the Pacific oyster Crassostrea gigas following chronic exposure to ionizing radiation
作者: Devos A.; Dallas L.J.; Voiseux C.; Lecomte-Pradines C.; Jha A.N.; Fiévet B.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2015
卷: 95, 期:2
起始页码: 688
结束页码: 698
语种: 英语
英文关键词: Crassostrea gigas ; DNA damage ; Gene expression ; Growth ; Ionizing radiation ; Juveniles
Scopus关键词: DNA ; Genes ; Growth (materials) ; Ionizing radiation ; Marine biology ; Marine pollution ; Molluscs ; Nuclear energy ; Radiation shielding ; Shellfish ; Anthropogenic contaminants ; Biological organization ; Crassostrea gigas ; DNA damages ; Genotoxic response ; Juveniles ; Physiological effects ; Stress-related gene ; Gene expression ; cytochrome P450 1A ; glutathione transferase ; heat shock protein 70 ; heat shock protein 90 ; melatonin 1 receptor ; melatonin 2 receptor ; multidrug resistance protein ; protein p53 ; superoxide dismutase ; mutagenic agent ; water pollutant ; anthropogenic source ; bioaccumulation ; bioassay ; DNA ; gene expression ; genotoxicity ; growth response ; ionization ; mollusc ; physiological response ; radiation exposure ; radionuclide ; adult ; animal experiment ; animal tissue ; Article ; blood cell count ; clearance ; concentration (parameters) ; controlled study ; Crassostrea gigas ; CYP1A gene ; DNA strand breakage ; environmental impact assessment ; gene expression ; gene targeting ; genetic analysis ; genetic code ; genotoxicity ; growth rate ; GST gene ; Hsc72 gene ; Hsp70 gene ; Hsp90 gene ; ionizing radiation ; larval development ; long term exposure ; marker gene ; MDR gene ; MT1 gene ; MT2 gene ; nonhuman ; nuclear power plant ; radiation exposure ; SOD gene ; survival rate ; tumor suppressor gene ; young adult ; animal ; comet assay ; Crassostrea ; DNA damage ; gene expression ; genetics ; ionizing radiation ; metabolism ; physiological stress ; physiology ; radiation monitoring ; toxicity ; toxicity testing ; water pollutant ; Crassostrea gigas ; Ostreidae ; Animals ; Comet Assay ; Crassostrea ; DNA Damage ; Gene Expression ; Mutagens ; Radiation Monitoring ; Radiation, Ionizing ; Stress, Physiological ; Toxicity Tests, Chronic ; Water Pollutants, Radioactive
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science ; Earth and Planetary Sciences: Oceanography ; Environmental Science: Pollution
英文摘要: Marine organisms are exposed to low doses of anthropogenic contaminants during their entire life. Authorized amounts of radionuclides are discharged in the Channel by nuclear facilities. The Pacific oyster was used to investigate the potential impact of chronic exposure to ionizing radiation. Though we exposed larvae and spat for two weeks to much higher concentrations than those encountered near nuclear facilities, oyster growth and expression of 9 selected stress genes were not significantly changed. To determine potential DNA damage, 2. year old oysters were exposed for two weeks to tritiated water. The comet assay was used to evaluate the level of DNA strand breaks in haemocytes, whilst the 'clearance rate' was used as a measure of physiological effects. Whilst other parameters did not alter, DNA damage significantly increased. Our results highlight the significance of the observed DNA damage and their potential consequences at higher levels of biological organization. © 2015 Elsevier Ltd.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/86034
Appears in Collections:过去全球变化的重建
全球变化的国际研究计划

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作者单位: Institut de Radioprotection et de SÛreté Nucléaire, PRP-ENV/SERIS/Laboratoire de Radioécologie de Cherbourg-Octeville, Rue Max Pol Fouchet, BP 10, Cherbourg Octeville, France; University of Plymouth, School of Biological Sciences, Plymouth, United Kingdom; Institut de Radioprotection et de SÛreté Nucléaire, PRP-ENV/SERIS/Laboratoire d'ECOtoxicologie des radionucléides, BP 3, Saint-Paul-Lez-Durance Cedex, France

Recommended Citation:
Devos A.,Dallas L.J.,Voiseux C.,et al. Assessment of growth, genotoxic responses and expression of stress related genes in the Pacific oyster Crassostrea gigas following chronic exposure to ionizing radiation[J]. Marine Pollution Bulletin,2015-01-01,95(2)
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