DOI: 10.1016/j.marpolbul.2015.03.036
Scopus记录号: 2-s2.0-84933675884
论文题名: The sub-cellular fate of mercury in the liver of wild mullets (Liza aurata) - Contribution to the understanding of metal-induced cellular toxicity
作者: Araújo O. ; Pereira P. ; Cesário R. ; Pacheco M. ; Raimundo J.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2015
卷: 95, 期: 1 起始页码: 412
结束页码: 418
语种: 英语
英文关键词: Liver
; Liza aurata
; Mercury
; Ria de Aveiro
; Sub-cellular partition
Scopus关键词: Detoxification
; Fish
; Liver
; Mercury (metal)
; Proteins
; Environmental difference
; Heat-denaturable proteins
; Liza aurata
; Mercury concentrations
; Ria de Aveiro
; Sediment contamination
; Sub-cellular
; Sub-cellular partitioning
; Mobile security
; mercury
; surface water
; mercury
; water pollutant
; concentration (composition)
; finfish
; mercury (element)
; partitioning
; sediment pollution
; toxicity
; water pollution
; Article
; benthos
; cell fate
; concentration (parameters)
; controlled study
; cytotoxicity
; detoxification
; fish
; heavy metal poisoning
; intracellular space
; liver homogenate
; liver toxicity
; Liza aurata
; lysosome
; metal induced cellular toxicity
; microsome
; mitochondrion
; nonhuman
; pelagic species
; pollutant
; protein denaturation
; sediment
; water contamination
; analysis
; animal
; cytology
; drug effects
; drug inactivation
; liver
; metabolism
; pharmacokinetics
; Portugal
; Smegmamorpha
; water pollutant
; Aveiro [Portugal]
; Portugal
; Ria de Aveiro
; Liza aurata
; Mugilidae
; Animals
; Inactivation, Metabolic
; Liver
; Lysosomes
; Mercury
; Mitochondria
; Portugal
; Smegmamorpha
; Water Pollutants, Chemical
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: Mercury is a recognized harmful pollutant in aquatic systems but still little is known about its sub-cellular partitioning in wild fish. Mercury concentrations in liver homogenate (whole organ load) and in six sub-cellular compartments were determined in wild Liza aurata from two areas - contaminated (LAR) and reference. Water and sediment contamination was also assessed. Fish from LAR displayed higher total mercury (tHg) organ load as well as in sub-cellular compartments than those from the reference area, reflecting environmental differences. However, spatial differences in percentage of tHg were only observed for mitochondria (Mit) and lysosomes plus microsomes (Lys. +. Mic). At LAR, Lys. +. Mic exhibited higher levels of tHg than the other fractions. Interestingly, tHg in Mit, granules (Gran) and heat-denaturable proteins was linearly correlated with the whole organ. Low tHg concentrations in heat stable proteins and Gran suggests that accumulated levels might be below the physiological threshold to activate those detoxification fractions. © 2015 Elsevier Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/86073
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: IPMA - Portuguese Institute for the Sea and Atmosphere, Av. Brasília, Lisbon, Portugal; CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, Rua dos Bragas, Porto, Portugal; Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal; Centro de Química Estrutural, Instituto Superior técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisboa, Portugal
Recommended Citation:
Araújo O.,Pereira P.,Cesário R.,et al. The sub-cellular fate of mercury in the liver of wild mullets (Liza aurata) - Contribution to the understanding of metal-induced cellular toxicity[J]. Marine Pollution Bulletin,2015-01-01,95(1)