DOI: 10.1016/j.marpolbul.2015.11.009
Scopus记录号: 2-s2.0-84954266356
论文题名: Developmental toxicity of three hexabromocyclododecane diastereoisomers in embryos of the marine medaka Oryzias melastigma
作者: Hong H. ; Shen R. ; Liu W. ; Li D. ; Huang L. ; Shi D.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2015
卷: 101, 期: 1 起始页码: 110
结束页码: 118
语种: 英语
英文关键词: Developmental toxicity
; Diastereoisomers
; Hexabromocyclododecanes
; Oryzias melastigma
; Oxidative stress
Scopus关键词: Cell death
; Oxidative stress
; Developmental toxicity
; Diastereoisomers
; Hexabromocyclododecanes
; Marine biota
; Oryzias melastigma
; Reactive oxygen species
; Toxicity assessment
; Zebrafish embryos
; Toxicity
; alpha hexabromocyclododecane
; beta hexabromocyclododecane
; caspase 3
; caspase 8
; caspase 9
; gamma hexabromocyclododecane
; hexabromocyclododecane
; reactive oxygen metabolite
; unclassified drug
; brominated hydrocarbon
; hexabromocyclododecane
; reactive oxygen metabolite
; water pollutant
; bromine compound
; ecotoxicology
; embryo
; fish
; marine pollution
; organic compound
; oxidation
; physiological response
; pollution monitoring
; reaction kinetics
; apoptosis
; Article
; controlled study
; developmental toxicity
; diastereoisomer
; embryo
; enzyme activity
; extraction
; gene expression
; genetic transcription
; heart beat
; high performance liquid chromatography
; mass spectrometry
; nonhuman
; Oryzias
; Oryzias melastigma
; oxidative stress
; purification
; real time polymerase chain reaction
; toxicity testing
; TUNEL assay
; Western blotting
; animal
; chemistry
; congenital malformation
; drug effects
; embryology
; environmental monitoring
; gene expression regulation
; genetics
; heart
; metabolism
; nonmammalian embryo
; organogenesis
; pathology
; procedures
; stereoisomerism
; tandem mass spectrometry
; toxicity
; water pollutant
; Danio rerio
; Oryzias melastigma
; Oryziinae
; Animals
; Apoptosis
; Chromatography, High Pressure Liquid
; Embryo, Nonmammalian
; Environmental Monitoring
; Gene Expression Regulation, Developmental
; Heart
; Hydrocarbons, Brominated
; Organogenesis
; Oryzias
; Reactive Oxygen Species
; Stereoisomerism
; Tandem Mass Spectrometry
; Water Pollutants, Chemical
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: The composition of major hexabromocyclododecane (HBCD) diastereoisomers, i.e. α-, β-, and γ-HBCDs, in marine biota is different from that of the commercially available form (technical HBCD), which is used extensively for toxicological studies. To properly evaluate the impact of HBCDs, the embryos of Oryzias melastigma were used to examine the developmental toxicity of the individual diastereoisomers. Results showed that HBCD diastereoisomers at the environmentally realistic concentrations in the embryos induced malformation rate and heartbeat, and caused the appearance of apoptotic heart. In addition, α-, β-, and γ-HBCDs had similar potency to stimulate the generation of reactive oxygen species, consequently leading to apoptosis in O. melastigma embryos. The order of the developmental toxicity of α-, β-, and γ-HBCDs in O. melastigma embryos was different from that in zebrafish embryos studied previously, which highlighted the importance of using species from both fresh and salt water for toxicity assessment. © 2015 Elsevier Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/86453
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, China; Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, Xiamen University, Xiamen, China; College of the Environment and Ecology, Xiamen University, Xiamen, China; State Key Laboratory of Marine Environmental Science, College of the Environment and Ecology, Xiamen University, South Xiangan Rd, Xiangan District, Xiamen, Fujian, China
Recommended Citation:
Hong H.,Shen R.,Liu W.,et al. Developmental toxicity of three hexabromocyclododecane diastereoisomers in embryos of the marine medaka Oryzias melastigma[J]. Marine Pollution Bulletin,2015-01-01,101(1)