DOI: 10.1016/j.marpolbul.2016.07.031
Scopus记录号: 2-s2.0-84990909783
论文题名: A novel biomarker for marine environmental pollution of HSP90 from Mytilus coruscus
作者: Liu H. ; Wu J. ; Xu M. ; He J.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2016
卷: 111, 期: 2018-01-02 起始页码: 428
结束页码: 434
语种: 英语
英文关键词: Environmental stress
; Heat shock protein 90 (HSP90)
; Mytilus coruscus
; Vibrio infection
Scopus关键词: Marine pollution
; Environmental pollutions
; Environmental stress
; Heat-shock protein 90
; Molecular chaperones
; Mytilus
; Phylogenetic relationships
; Vibrio alginolyticus
; Vibrio infection
; Proteins
; adenosine triphosphate
; biological marker
; cadmium
; copper
; guanosine triphosphate
; heat shock protein 90
; messenger RNA
; biological marker
; cadmium
; complementary DNA
; copper
; heat shock protein 90
; water pollutant
; biomarker
; DNA
; environmental stress
; heat shock
; marine pollution
; mollusc
; phylogenetics
; protein
; adult
; animal tissue
; Article
; binding site
; controlled study
; environmental stress
; hemolymph
; Mytilus
; Mytilus coruscus
; nonhuman
; nucleotide sequence
; phylogeny
; protein expression
; protein motif
; sea pollution
; upregulation
; Vibrio alginolyticus
; Vibrio harveyi
; amino acid sequence
; analysis
; animal
; conserved sequence
; drug effects
; gene expression regulation
; genetics
; metabolism
; Mytilus
; pathogenicity
; physiological stress
; physiology
; toxicity
; Vibrio
; water pollutant
; water pollution
; Mollusca
; Mytilus coruscus
; Vibrio
; Vibrio alginolyticus
; Vibrio harveyi
; Amino Acid Sequence
; Animals
; Binding Sites
; Biomarkers
; Cadmium
; Conserved Sequence
; Copper
; DNA, Complementary
; Gene Expression Regulation
; Hemolymph
; HSP90 Heat-Shock Proteins
; Mytilus
; Phylogeny
; Stress, Physiological
; Vibrio
; Water Pollutants, Chemical
; Water Pollution
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: Heat shock protein 90 (HSP90) is a conserved molecular chaperone contributing to cell cycle control, organism development and the proper regulation of cytosolic proteins. The full-length HSP90 cDNA of Mytilus coruscus (McHSP90, KT946644) was 2420 bp, including an ORF of 2169 bp encoding a polypeptide of 722 amino acids with predicted pI/MW 4.89/83.22 kDa. BLASTp analysis and phylogenetic relationship strongly suggested McHSP90 was a member of HSP90 family, and it was highly conserved with other known HSP90, especially in the HSP90 family signatures, ATP/GTP-Binding sites and ‘EEVD’ motif. The mRNA of McHSP90 in haemolymph was upregulated in all treatments including Vibrio alginolyticus and Vibrio harveyi challenge, metals stresses (copper and cadmium) and 180 CST fuel exposure. All the results implied the expression of McHSP90 could be affected by Vibrio challenge and environmental stress, which might help us gain more insight into the molecular mechanism of HSP against adverse stresses in mollusca. © 2016 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/86733
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: National Engineering Research Center of Marine Facilities Aquaculture, Zhejiang Ocean University, Zhoushan, China
Recommended Citation:
Liu H.,Wu J.,Xu M.,et al. A novel biomarker for marine environmental pollution of HSP90 from Mytilus coruscus[J]. Marine Pollution Bulletin,2016-01-01,111(2018-01-02)