DOI: 10.1016/j.marpolbul.2016.06.086
Scopus记录号: 2-s2.0-84978472258
论文题名: Antibiotic and metal resistance in a ST395 Pseudomonas aeruginosa environmental isolate: A genomics approach
作者: Teixeira P. ; Tacão M. ; Alves A. ; Henriques I.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2016
卷: 110, 期: 1 起始页码: 75
结束页码: 81
语种: 英语
英文关键词: Co-selection
; Environment
; Genome sequencing
; Opportunistic pathogen
; Pseudomonas aeruginosa
; Resistome
Scopus关键词: antiinfective agent
; heavy metal
; bacterial gene
; bacterium identification
; chemistry
; drug effects
; genetics
; genomics
; microbial sensitivity test
; multilocus sequence typing
; phylogeny
; Pseudomonas aeruginosa
; Anti-Bacterial Agents
; Bacterial Typing Techniques
; Genes, Bacterial
; Genomics
; Metals, Heavy
; Microbial Sensitivity Tests
; Multilocus Sequence Typing
; Phylogeny
; Pseudomonas aeruginosa
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: We analyzed the resistome of Pseudomonas aeruginosa E67, an epiphytic isolate from a metal-contaminated estuary. The aim was to identify genetic determinants of resistance to antibiotics and metals, assessing possible co-selection mechanisms. Identification was based on phylogenetic analysis and average nucleotide identity value calculation. MLST affiliated E67 to ST395, previously described as a high-risk clone. Genome analysis allowed identifying genes probably involved in resistance to antibiotics (e.g. beta-lactams, aminoglycosides and chloramphenicol) and metals (e.g. mercury and copper), consistent with resistance phenotypes. Several genes associated with efflux systems, as well as genetic determinants contributing to gene motility, were identified. Pseudomonas aeruginosa E67 possesses an arsenal of resistance determinants, probably contributing to adaptation to a polluted ecosystem. Association to mobile structures highlights the role of these platforms in multi-drug resistance. Physical links between metal and antibiotic resistance genes were not identified, suggesting a predominance of cross-resistance associated with multidrug efflux pumps. © 2016 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/86854
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: Biology Department, CESAM & IBIMED, University of Aveiro, Aveiro, Portugal; Biology Department, CESAM, University of Aveiro, Aveiro, Portugal
Recommended Citation:
Teixeira P.,Tacão M.,Alves A.,et al. Antibiotic and metal resistance in a ST395 Pseudomonas aeruginosa environmental isolate: A genomics approach[J]. Marine Pollution Bulletin,2016-01-01,110(1)