DOI: 10.1016/j.marpolbul.2016.02.064
Scopus记录号: 2-s2.0-84960533518
论文题名: Effects of emerging contaminants on neurotransmission and biotransformation in marine organisms - An in vitro approach
作者: Luis L.G. ; Barreto Â. ; Trindade T. ; Soares A.M.V.M. ; Oliveira M.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2016
卷: 106, 期: 2018-01-02 起始页码: 236
结束页码: 244
语种: 英语
英文关键词: Gold nanoparticles
; Human pharmaceuticals
; Mixtures
; Mytilus galloprovincialis
; Neurotransmission
; Phase II biotransformation
Scopus关键词: Bioconversion
; Body fluids
; Enzymes
; Gold
; Marine biology
; Marine pollution
; Mixtures
; Nanoparticles
; Gold Nanoparticles
; Human pharmaceuticals
; Mytilus galloprovincialis
; Neurotransmission
; Phase II
; Amides
; acetylcholinesterase
; bovine serum albumin
; carbamazepine
; citric acid
; fluoxetine
; glutathione transferase
; gold nanoparticle
; nanoparticle
; povidone
; acetylcholinesterase
; glutathione transferase
; water pollutant
; biotransformation
; bivalve
; drug
; enzyme activity
; gold
; marine pollution
; nanoparticle
; pollution effect
; toxicity
; animal experiment
; Article
; biotransformation
; cell fractionation
; controlled study
; enzyme activity
; gill
; hemolymph
; IC50
; in vitro study
; incubation time
; marine species
; mussel
; Mytilus galloprovincialis
; neurotransmission
; nonhuman
; persistent organic pollutant
; validation process
; waste water management
; animal
; aquatic species
; biotransformation
; environmental monitoring
; metabolism
; Mytilus
; synaptic transmission
; water pollutant
; Bovinae
; Mytilus galloprovincialis
; Acetylcholinesterase
; Animals
; Aquatic Organisms
; Biotransformation
; Carbamazepine
; Environmental Monitoring
; Gills
; Glutathione Transferase
; Mytilus
; Synaptic Transmission
; Water Pollutants, Chemical
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: The effects of gold (ionic form and nanoparticles - AuNPs) and pharmaceuticals (carbamazepine and fluoxetine) on enzymes involved in neurotransmission (acetylcholinesterase - AChE) and biotransformation (glutathione S-transferases - GST) were assessed by their incubation with Mytilus galloprovincialis' hemolymph and subcellular fraction of gills, respectively. AuNPs did not alter enzymatic activities unlike ionic gold that inhibited AChE and GST activities at 2.5 and 0.42 mg·L-1, respectively. Carbamazepine inhibited AChE activity at 500 mg·L-1 and fluoxetine at 1000 mg·L-1. GST was inhibited by carbamazepine at 250 mg·L-1 and by fluoxetine at 125 mg·L-1. Increased AChE activity was found in simultaneous exposures to fluoxetine and bovine serum albumin coated AuNPs (BSA-AuNPs). Concerning GST, in the simultaneous exposures, AuNPs revealed protective effects against carbamazepine (citrate and polyvinylpyrrolidone coated) and fluoxetine (citrate and BSA coated) induced inhibition. However, BSA-AuNPs increased the inhibition caused by carbamazepine. AuNPs demonstrated ability to interfere with other chemicals toxicity justifying further studies. © 2016 Elsevier Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/87334
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal; Department of Chemistry and CICECO, University of Aveiro, Aveiro, Portugal
Recommended Citation:
Luis L.G.,Barreto Â.,Trindade T.,et al. Effects of emerging contaminants on neurotransmission and biotransformation in marine organisms - An in vitro approach[J]. Marine Pollution Bulletin,2016-01-01,106(2018-01-02)