DOI: 10.1016/j.marpolbul.2017.07.039
Scopus记录号: 2-s2.0-85026192214
论文题名: Biomarker responses of Cu-induced toxicity in European seabass Dicentrarchus labrax: Assessing oxidative stress and histopathological alterations
作者: Díaz-de-Alba M. ; Canalejo Raya A. ; Granado-Castro M.D. ; Oliva Ramírez M. ; El Mai B. ; Córdoba García F. ; Troyano-Montoro M. ; Espada-Bellido E. ; Torronteras Santiago R. ; Galindo-Riaño M.D.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2017
卷: 124, 期: 1 起始页码: 336
结束页码: 348
语种: 英语
英文关键词: Biomarkers
; Copper
; Dicentrarchus labrax
; Histopathological alterations
; Oxidative stress
Scopus关键词: Copper
; Enzymes
; Fish
; Lipids
; Oxidation
; Oxidative stress
; Oxygen
; Peptides
; Toxicity
; Anti-oxidant response
; Dicentrarchus labrax
; Environmental standards
; Glutathione peroxidase
; Histopathological alterations
; Metal concentrations
; Oxidative stress biomarkers
; Super oxide dismutase
; Biomarkers
; catalase
; copper
; glutathione peroxidase
; superoxide dismutase
; antioxidant
; bioaccumulation
; biomarker
; biomonitoring
; copper
; fish
; histopathology
; oxidative stress
; pollution effect
; pollution exposure
; toxicity
; animal tissue
; Article
; bioaccumulation
; brain
; concentration (parameters)
; controlled study
; environmental monitoring
; enzyme activity
; European sea bass
; gill
; histopathology
; limit of detection
; limit of quantitation
; lipid peroxidation
; liver
; measurement accuracy
; muscle
; nonhuman
; oxidative stress
; reliability
; water pollution
; Dicentrarchus labrax
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: A comprehensive approach to chemical accumulation and biological effects of short-term Cu exposure in juveniles of European seabass (Dicentrarchus labrax) has been achieved. Fish were exposed to 0.01–10 mg L− 1 nominal Cu concentrations for 24–96 h. Metal concentrations in water and gills, liver, muscle and brain tissues were studied along with oxidative stress biomarkers (superoxide dismutase, catalase, glutathione peroxidase, lipid peroxidation). Induction of oxidative damage was observed in all the organs with differential antioxidant responses; gills appearing as the most sensitive from low environmentally water Cu concentrations as 0.01 mg L− 1. Histopathological alterations were also observed in liver and gills, even without a significant Cu accumulation. The results show that the combination of oxidative stress parameters, particularly lipid peroxidation and glutathione peroxidase activities, and histopathological alterations provide a good model fish and reliable early biomarkers for monitoring Cu pollution in seawater and might call for the protection agencies to revise the Cu environmental standards. © 2017 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/87422
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: Department of Analytical Chemistry, Institute of Biomolecules (INBIO), Faculty of Sciences, CEI-MAR, University of Cadiz, Campus Rio San Pedro, Puerto Real, Cadiz, Spain; Department of Integrated Sciences, Faculty of Experimental Sciences, CEI-MAR, University of Huelva, Avda. Fuerzas Armadas, Huelva, Spain; Department of Biology, Faculty of Sea and Environmental Sciences, CEI-MAR, University of Cadiz, Campus Rio San Pedro, Puerto Real, Cadiz, Spain
Recommended Citation:
Díaz-de-Alba M.,Canalejo Raya A.,Granado-Castro M.D.,et al. Biomarker responses of Cu-induced toxicity in European seabass Dicentrarchus labrax: Assessing oxidative stress and histopathological alterations[J]. Marine Pollution Bulletin,2017-01-01,124(1)