DOI: 10.1016/j.marpolbul.2017.08.043
Scopus记录号: 2-s2.0-85028029224
论文题名: Exposure to crack cocaine causes adverse effects on marine mussels Perna perna
作者: Maranho L.A. ; Fontes M.K. ; Kamimura A.S.S. ; Nobre C.R. ; Moreno B.B. ; Pusceddu F.H. ; Cortez F.S. ; Lebre D.T. ; Marques J.R. ; Abessa D.M.S. ; Ribeiro D.A. ; Pereira C.D.S.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2017
卷: 123, 期: 2018-01-02 起始页码: 410
结束页码: 414
语种: 英语
英文关键词: Bioassays
; Crack cocaine
; Cyto-genotoxicity
; Marine organism
Scopus关键词: Bioassay
; Cracks
; Ecosystems
; Marine biology
; Molluscs
; Contaminants of emerging concerns
; Ecotoxicological study
; Effect concentration
; Fertilization rates
; Genotoxicities
; Larval development
; Lysosomal membrane stabilities
; Marine organisms
; Marine pollution
; cocaine
; bioassay
; DNA
; drug
; embryonic development
; genotoxicity
; larval development
; mollusc
; animal tissue
; Article
; bioaccumulation
; controlled study
; cytotoxicity
; DNA strand breakage
; ecotoxicology
; embryo development
; embryotoxicity
; gamete
; genotoxicity
; IC50
; larval development
; nonhuman
; Perna perna
; Mytilidae
; Perna perna
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: Our study aimed to evaluate crack cocaine effects in different life stages of the marine mussel Perna perna. For this purpose, fertilization rate, embryo-larval development, lysosomal membrane stability and DNA strand breaks were assessed. Effect concentrations in gametes and in larval development were found after 1 h (IC50 = 23.53 mg·L− 1) and 48 h (IC50 = 16.31 mg·L− 1), respectively. The highest tested concentration showing no acute toxicity (NOEC) was 10 mg·L− 1, while the lowest observed effect concentration (LOEC) was 20 mg·L− 1. NOEC concerning embryo-larval development was 0.625 mg·L− 1, while the LOEC was 1.25 mg·L− 1. Cyto-genotoxic effects were evidenced in mussels exposed to crack cocaine concentrations ranging from 5 to 500 μg·L− 1. Our results report the first data on effects of an illicit drug to marine organisms and should encourage further ecotoxicological studies of these contaminants of emerging concern in coastal ecosystems. © 2017 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/87509
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: Departamento de Ciências do Mar, Universidade Federal de São Paulo, Rua Dr. Carvalho de Mendonça, 144, Santos, Brazil; Laboratório de Ecotoxicologia, Universidade Santa Cecília, Rua Oswaldo Cruz 266, Santos, Brazil; CEMSA – Centro de Espectrometria de Massas Aplicada, CIETEC/IPEN, Av. Prof. Lineu Prestes, 2242, Salas 112 e 113, São Paulo, Brazil; Instituto de Biociências, Campus do Litoral Paulista, Universidade Estadual Paulista “Júlio de Mesquita Filho”, Infante Dom Henrique, s/n, São Vicente, Brazil; Departamento de Biociências, Universidade Federal de São Paulo, Av. Ana Costa 95, Santos, Brazil
Recommended Citation:
Maranho L.A.,Fontes M.K.,Kamimura A.S.S.,et al. Exposure to crack cocaine causes adverse effects on marine mussels Perna perna[J]. Marine Pollution Bulletin,2017-01-01,123(2018-01-02)