DOI: 10.1016/j.marpolbul.2017.04.007
Scopus记录号: 2-s2.0-85018992736
论文题名: Elevated gonadal atresia as biomarker of endocrine disruptors: Field and experimental studies using Mytilus trossulus (L.) and 17-alpha ethinylestradiol (EE2)
作者: Smolarz K. ; Hallmann A. ; Zabrzańska S. ; Pietrasik A.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2017
卷: 120, 期: 2018-01-02 起始页码: 58
结束页码: 67
语种: 英语
英文关键词: Baltic Sea
; Endocrine disruptors
; Gonadal abnormalities
; Mytilus trossulus
Scopus关键词: Endocrine disrupters
; Molluscs
; Organic pollutants
; Baltic sea
; Biomonitoring studies
; Endocrine disrupting compound
; Endocrine disruptor
; Gonadal abnormalities
; Mytilus trossulus
; Seminiferous tubules
; Spatial differences
; Biomarkers
; endocrine disruptor
; ethinylestradiol
; biological marker
; abnormality
; bioaccumulation
; biomarker
; biomonitoring
; bivalve
; endocrine disruptor
; infiltration
; marine pollution
; purification
; animal experiment
; animal tissue
; Article
; Baltic Sea
; biological monitoring
; bivalve
; blood cell
; cell infiltration
; controlled study
; environmental exposure
; female
; gonad tumor
; gonadal atresia
; gonadal disease
; histopathology
; male
; mussel
; Mytilus
; Mytilus trossulus
; nonhuman
; seminiferous tubule
; sex difference
; water pollution
; animal
; Baltic States
; disorder of sex development
; gonad
; Mytilus
; pathology
; toxicity
; veterinary
; water pollutant
; Atlantic Ocean
; Baltic Sea
; Bivalvia
; Mytilus trossulus
; Animals
; Baltic States
; Biomarkers
; Disorders of Sex Development
; Endocrine Disruptors
; Female
; Gonads
; Male
; Mytilus
; Water Pollutants, Chemical
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: In the present work we compared the type and frequency of gonadal abnormalities among Mytilus trossulus populations from the Gulf of Gdańsk, Baltic Sea. Observed histopathologies were grouped as regressive changes (RC, gonadal atresia (GA) and regression (GR)), progressive changes (PC, gonadal tumors) and intersex. Sex-based and spatial differences in frequency of RC were found, with the highest frequency of RC and PC found in mussels from polluted station B followed by mussels from station A located near a purification plant outlet. Bivalves from the reference area had the lowest frequency of RC. In order to confirm biomarker applicability of RC, an exposure experiment with model xenoestrogen 17α-ethinylestradiol (EE2) was performed. The exposure of M. trossulus to 50 and 500 ng dL− 1 of EE2 resulted in an increased frequency of gonadal regression and atresia, including melanized hemocytes infiltration in seminiferous tubules. We thus suggest that these changes can serve as biomarkers of endocrine disrupting compounds in biomonitoring studies. © 2017 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/88083
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: Department of Marine Ecosystem Functioning, University of Gdańsk, Al. Piłsudskiego 46, Gdynia, Poland; Department of Pharmaceutical Biochemistry, Medical University of Gdańsk, ul. Dębinki 1, Gdańsk, Poland; Department of Marine Biotechnology, University of Gdańsk, Al. Piłsudskiego 46, Gdynia, Poland
Recommended Citation:
Smolarz K.,Hallmann A.,Zabrzańska S.,et al. Elevated gonadal atresia as biomarker of endocrine disruptors: Field and experimental studies using Mytilus trossulus (L.) and 17-alpha ethinylestradiol (EE2)[J]. Marine Pollution Bulletin,2017-01-01,120(2018-01-02)