DOI: 10.1016/j.marpolbul.2017.06.006
Scopus记录号: 2-s2.0-85020425979
论文题名: Bioaccumulation of sulfadiazine and subsequent enzymatic activities in Chinese mitten crab (Eriocheir sinensis)
作者: Cheng L. ; Chen Y. ; Zheng Y.Y. ; Zhan Y. ; Zhao H. ; Zhou J.L.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2017
卷: 121, 期: 2018-01-02 起始页码: 176
结束页码: 182
语种: 英语
英文关键词: Acetylcholinesterase
; Alkaline phosphatase
; Bioaccumulation
; Chinese mitten crab
; Sulfadiazine residues
Scopus关键词: Bioaccumulation
; Biochemistry
; Histology
; Phosphatases
; Tissue
; Tissue engineering
; Acetylcholinesterase
; Acetylcholinesterase activity
; ALkaline phosphatase
; Chinese mitten crabs
; Enzymatic activities
; Negative correlation
; Sulfadiazine residues
; Ultrasound extractions
; Shellfish
; acetylcholinesterase
; alkaline phosphatase
; sulfadiazine
; superoxide dismutase
; sulfadiazine
; antibiotics
; bioaccumulation
; crab
; enzyme
; enzyme activity
; metabolism
; phosphatase
; adult
; animal experiment
; animal tissue
; Article
; bioaccumulation
; concentration (parameters)
; controlled study
; correlation analysis
; crab
; drug exposure
; enzyme activity
; enzyme metabolism
; Eriocheir sinensis
; gill
; liver tissue
; microcosm
; muscle tissue
; nonhuman
; process optimization
; residue analysis
; animal
; Brachyura
; chemistry
; enzymology
; liver
; pharmacokinetics
; skeletal muscle
; tissue distribution
; toxicity
; water pollutant
; Decapoda (Crustacea)
; Eriocheir sinensis
; Animals
; Brachyura
; Gills
; Liver
; Muscle, Skeletal
; Sulfadiazine
; Tissue Distribution
; Water Pollutants, Chemical
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: The bioaccumulation of sulfadiazine and subsequent enzymatic activities in Chinese mitten crab (Eriocheir sinensis) were studied in microcosms, by exposing to 50, 100, 500 and 1000 ng/L of sulfadiazine for 44 days. An effective method for extracting sulfadiazine in crab tissues was established by modifying the cleanup method after ultrasound extraction, with improved recoveries of 61.8%, 93.7% and 100.5% in gill, muscle and liver samples. The results showed that sulfadiazine residues were all < 3 ng/g dry weight in different tissues, and that sulfadiazine bioaccumulation in crab was not dose-dependent. A significantly negative correlation was observed between acetylcholinesterase activity and the residue concentration of sulfadiazine during exposure to 50 ng/L and 1000 ng/L, and between alkaline phosphatase and sulfadiazine residues in the 100 ng/L exposure group in the gill, suggesting that the two enzymes played an important role in the metabolism of sulfadiazine in crab. © 2017 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/88125
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: State Key Laboratory of Estuarine and Coastal Research, East China Normal University, 3663 North Zhongshan Road, Shanghai, China
Recommended Citation:
Cheng L.,Chen Y.,Zheng Y.Y.,et al. Bioaccumulation of sulfadiazine and subsequent enzymatic activities in Chinese mitten crab (Eriocheir sinensis)[J]. Marine Pollution Bulletin,2017-01-01,121(2018-01-02)