DOI: 10.1016/j.marpolbul.2018.03.057
Scopus记录号: 2-s2.0-85044986175
论文题名: Tissue-specific metabolic responses of the pearl oyster Pinctada martensii exposed to benzo[a]pyrene
作者: Chen H. ; Diao X. ; Zhou H.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2018
卷: 131 起始页码: 17
结束页码: 21
语种: 英语
英文关键词: 1H NMR
; Benzo[a]pyrene
; Biomarker
; Metabolomics
; Pinctada martensii
Scopus关键词: Biomarkers
; Biomolecules
; Marine pollution
; Metabolism
; Metabolites
; Osmosis
; Physiology
; Pyrene
; Tissue
; Benzo [a] pyrene
; Carcinogenic effects
; Energy metabolism
; Metabolic response
; Metabolite changes
; Metabolomics
; Pinctada martensii
; Polycyclic aromatic hydrocarbon (PAH)
; Barium compounds
; amino acid
; benzo[a]pyrene
; biological marker
; biomarker
; bivalve
; metabolism
; metabolite
; PAH
; pollution exposure
; adult
; animal tissue
; Article
; controlled study
; energy metabolism
; environmental exposure
; exocrine gland
; gill
; metabolic disorder
; metabolism
; metabolite
; metabolomics
; neurotoxicity
; nonhuman
; osmotic stress
; Pinctada
; tissue specificity
; water pollution
; Pinctada
; Pinctada martensi
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that is well known for its teratogenic, mutagenic and carcinogenic effects. In this study, we applied metabolomics to investigate the tissue-specific metabolic responses of the Pinctada martensii digestive glands and gills after a short-duration exposure to BaP (1 μg/L and 10 μg/L). After 72 h of exposure to BaP, the majority of metabolite changes were related to osmolytes, energy metabolites, and amino acids. BaP (1 μg/L) accelerated energy deterioration and decreased osmotic regulation, while BaP (10 μg/L) disturbed energy metabolism and increased osmotic stress in the digestive glands. Both BaP doses disturbed osmotic regulation and energy metabolism in the gills. BaP also induced neurotoxicity in both tissues. These findings demonstrated that BaP exhibited tissue-specific metabolic responses in P. martensii. The difference in these metabolite responses between the digestive glands and gills might prove to be suitable biomarkers for indicating exposure to specific marine pollutants. © 2018 Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/88245
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, Haikou, China; Institute of Tropical Agriculture and Forestry, Hainan University, Haikou, China; Institute of Tropical Agriculture and Forestry, Hainan University, Haikou, Hainan, China
Recommended Citation:
Chen H.,Diao X.,Zhou H.. Tissue-specific metabolic responses of the pearl oyster Pinctada martensii exposed to benzo[a]pyrene[J]. Marine Pollution Bulletin,2018-01-01,131