DOI: 10.1016/j.marpolbul.2017.10.081
Scopus记录号: 2-s2.0-85032900521
论文题名: The anti-estrogenicity of chronic exposure to semicarbazide in female Japanese flounders (Paralichthys olivaceus), and its potential mechanisms
作者: Yue Z. ; Yu M. ; Zhao H. ; Wang J. ; Zhang X. ; Tian H. ; Wang W. ; Ru S.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2018
卷: 129, 期: 2 起始页码: 806
结束页码: 812
语种: 英语
英文关键词: Gamma-aminobutyric acid
; Hypothalamic-pituitary-gonadal axis
; Japanese flounder
; Kisspeptin
; Semicarbazide
Scopus关键词: Amino acids
; Biosynthesis
; Proteins
; Risk assessment
; Gamma-aminobutyric acids
; Hypothalamic-pituitary-gonadal axis
; Japanese flounder
; Kisspeptin
; Semicarbazide
; Marine pollution
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: This study investigated the anti-estrogenic effects of chronic exposure to a new marine pollutant, semicarbazide (SMC; 1, 10, and 100 μg/L), in female Paralichthys olivaceus, as well as the associated mechanism. After 130 days of exposure, plasma 17β-estradiol and testosterone concentrations, and hepatic estrogen receptors, vitellogenin, and choriogenin mRNA levels decreased significantly in SMC-exposed groups. Moreover, down-regulation of genes in the hypothalamic-pituitary-gonadal axis, including gonadotropin-releasing hormone, gonadotropic hormones and their receptors, the steroidogenic acute regulatory protein, 17α-hydroxylase, 17β-hydroxysteroid dehydrogenase, and cytochrome P450 19A, was observed after SMC exposure. Furthermore, the kisspeptin/g protein-coupled receptor 54 (kiss/gpr54) system and gamma-aminobutyric acid-ergic (GABAergic) system were also affected by SMC: SMC significantly down-regulated mRNA expression of kiss2, gpr54, and the GABA synthesis enzyme gad67. Our results demonstrated for the first time that environmentally relevant concentrations of SMC exerted anti-estrogenicity in female flounders, providing theoretical support for ecological risk assessments of SMC in marine environments. © 2017 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/88397
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: Marine Life Science College, Ocean University of China, Qingdao, China; Qingdao Institute for Food and Drug Control, Qingdao, China
Recommended Citation:
Yue Z.,Yu M.,Zhao H.,et al. The anti-estrogenicity of chronic exposure to semicarbazide in female Japanese flounders (Paralichthys olivaceus), and its potential mechanisms[J]. Marine Pollution Bulletin,2018-01-01,129(2)