DOI: 10.1016/j.marpolbul.2018.01.052
Scopus记录号: 2-s2.0-85044316534
论文题名: Inorganic arsenic causes apoptosis cell death and immunotoxicity on European sea bass (Dicentrarchus labrax)
作者: Cordero H. ; Morcillo P. ; Martínez S. ; Meseguer J. ; Pérez-Sirvent C. ; Chaves-Pozo E. ; Martínez-Sanchez M.J. ; Cuesta A. ; Ángeles Esteban M.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2018
卷: 128 起始页码: 324
结束页码: 332
语种: 英语
英文关键词: Apoptosis
; Arsenic
; European sea bass (Dicentrarchus labrax)
; Immunotoxicology
Scopus关键词: Arsenic
; Arsenic compounds
; Gene expression
; Water pollution
; Bactericidal activity
; Dicentrarchus labrax
; European sea bass
; Expression profile
; Immunotoxicology
; Peroxidase activities
; Respiratory burst
; Waterborne exposure
; Cell death
; arsenic
; caspase 3
; caspase 8
; caspase 9
; immunoglobulin M
; peroxidase
; protein Bax
; protein bcl 2
; apoptosis
; arsenic
; bioaccumulation
; cell
; immune system
; perciform
; pollution exposure
; toxicity
; animal experiment
; animal tissue
; apoptosis
; Article
; bax gene
; bioaccumulation
; casp3 gene
; casp8 gene
; casp9 gene
; cellular immunity
; controlled study
; European sea bass
; gene expression profiling
; gill
; histopathology
; immunotoxicity
; liver
; nonhuman
; proto oncogene
; respiratory burst
; sea pollution
; Dicentrarchus labrax
; Teleostei
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: Inorganic arsenic (As) is one of the most toxic pollutants in the water. We have studied their effects on the marine teleost European sea bass (Dicentrarchus labrax) at 2 and 10 days of 5 μM of As2O3 (sub-lethal doses) waterborne exposure. Arsenic accumulates in liver and gill tissues. The expression profile of five genes (bax, blc2, casp3, casp8 and casp9) involved in apoptosis cell death confirmed apoptotic effects in liver, slight changes in gill and no effects in skin according with the histopathology findings. Total IgM level and peroxidase activities were increased at 2 and 10 days, respectively. The bactericidal activity was decreased at 2 days after As exposure. A general decrease of cellular immune activities with significant differences in the case of respiratory burst activity was observed after 2 and 10 days of exposure. This work describes for the first time the effects of As exposure on European sea bass. © 2018 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/88442
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: Fish Innate Immune System Group, Department of Cell Biology and Histology, Faculty of Biology, Regional Campus of International Excellence “Campus Mare Nostrum”, University of Murcia, Murcia, Spain; Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Bronx, NY, United States; Department of Agricultural Chemistry, Geology and Pedology, Faculty of Chemistry, Campus Regional de Excelencia Internacional “Campus Mare Nostrum”, University of Murcia, Murcia, Spain; Centro Oceanográfico de Murcia, Instituto Español de Oceanografía (IEO), Carretera de la Azohía s/n., Puerto de Mazarrón, Murcia, Spain
Recommended Citation:
Cordero H.,Morcillo P.,Martínez S.,et al. Inorganic arsenic causes apoptosis cell death and immunotoxicity on European sea bass (Dicentrarchus labrax)[J]. Marine Pollution Bulletin,2018-01-01,128