| 项目编号: | 1726095
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| 项目名称: | MRI: Acquisition of a CytoViva system for highly interdisciplinary research and education in nanoscience and nanotechnology |
| 作者: | Ioana Sizemore
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| 承担单位: | Wright State University
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| 批准年: | 2017
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| 开始日期: | 2017-10-01
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| 结束日期: | 2020-09-30
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| 资助金额: | 289328
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | cytoviva system
; acquisition
; cytoviva technique
; interdisciplinary research project
; hyperspectral imaging system
; live biological system
; cytoviva optical microscope instrument
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| 英文摘要: | This project involves acquisition of a CytoViva optical microscope instrument that will benefit over 10 faculty and 100 undergraduate and graduate students (including underrepresented groups) at three Midwestern institutions of higher education, namely Wright State University (WSU), Otterbein University, Ohio, and Ball State University (BSU), Indiana. The cutting-edge equipment will facilitate the optical imaging and spectral confirmation of a wide range of nanomaterials in live biological systems or composite materials. Thereby, its acquisition will strengthen the research of these scientists and will lead to new interdisciplinary collaborations that will offer fundamental insight into critical nano-biomedical and environmental problems. The exploitation of the CytoViva system as a teaching tool will contribute to the development of modern academic curricula and the next generation of instrumentalists. Furthermore, over 100 high school students will be annually engaged in hands-on nano-related activities (Exploring STEMM Program at WSU). The scientific results and pedagogic materials will be shared with the scientific community at large and general public through various venues.
The proposed CytoViva system will consist of a high signal-to-noise-enhanced dark-field optical microscope and an integrated hyperspectral imaging system. It will be equipped with a proprietary Dual Fluorescence Module, which will facilitate the real time, simultaneous imaging of both fluorescently-labeled and non-labeled nanomaterials with high spectral. The CytoViva technique has the following unique capabilities: a) no sample preparation and no alteration in the targeted environment, b) improved time- and cost-efficiency, c) pixel-specific spectral data, and d) the capability of differentiating between similar nanostructures based on finite differences in their aggregation state, orientation, and functionalization. The breadth of interdisciplinary research projects impacted by the CytoViva system will include a) identifying the broad-spectrum antiviral mechanism of silver nanoparticles against deadly viruses, b) developing methodologies for studying the cellular trafficking and transformations of noble metal nanomaterials for biomedical applications, c) understanding the molecular basis of gene expression regulation involved in the antibiotic resistance of pathogenic bacteria using gold nanoparticles functionalized with aptamers, d) treating and detecting docetaxel resistant prostate cancer by targeted nanomedical formulation, and e) cytosolic mapping of digitalis Na/K-ATPase complex internalization as a potentially new cellular signaling mechanism. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/88724
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Ioana Sizemore. MRI: Acquisition of a CytoViva system for highly interdisciplinary research and education in nanoscience and nanotechnology. 2017-01-01.
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