| 项目编号: | 1704435
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| 项目名称: | Microfabricated devices for flexible sensing at the biointerface |
| 作者: | Vamsi Yadavalli
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| 承担单位: | Virginia Commonwealth University
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| 批准年: | 2017
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| 开始日期: | 2017-09-01
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| 结束日期: | 2020-08-31
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| 资助金额: | 300000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | soft tissue
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| 英文摘要: | Sensors that are biocompatible and biodegradable and are mechanically flexible and conform to soft tissues and organs in the human body are highly desirable as they provide a means to measure and monitor activity. In this research, biodegradable silk will be engineered and fabricated for testing of measurement feasibility of biomarkers that are indicative of pathology.
The project will investigate various electrochemical biosensor designs (1D wires, 2D sheets and 3D blocks) using biodegradable silk and conducting polymers in flexible and conformable formats for measuring such model biomarkers as acetylcholine, C-reactive protein, vascular endothelial growth factor (VEGF). The innovation proposed is the method of fabricating functional biosensors comprising the conducting polymer poly (3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) and silk proteins (fibroin and sericin) via techniques developed by silk protein lithography. The structure-property relationships of fabricated biosensors will be investigated through the following specific aims. (1) Investigate the compositional relationships that enhance electrochemical response and mechanical properties, and enable their selective detection, and (2) Investigate sensor fabrication strategies for sensors in multi-scales and dimensions (1-D wires, 2D sheets, and 3D scaffold network) so that they can conform to soft tissue. Appropriate recognition elements (antibody and aptamers) will be immobilized on electrode surface against the target analyte. Sensor response and mechanical properties will be engineered for conformable attachment to the target soft tissue while minimizing cytotoxicity. Feasibility sensor experiments will be conducted in vitro using stock seeds of cells under physiological conditions. Reproducibility of sensor response will be characterized and sensor design will be modified to accommodate required sensitivity, selectivity, and reproducibility. Education and outreach activities are proposed. Haptic and 3D printed models of micro and nanoscale objects will be fabricated to give students a direct visualization and textural feel for the various kinds of sensor architectures. Sharing of these in annual outreach activities organized by the PI will help inspire young students into engineering and science careers. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/89156
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Vamsi Yadavalli. Microfabricated devices for flexible sensing at the biointerface. 2017-01-01.
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