| 项目编号: | 1706513
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| 项目名称: | Next Generation Ca-P Cements for Treating Vertebral Body Fractures |
| 作者: | Sarit Bhaduri
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| 承担单位: | University of Toledo
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| 批准年: | 2017
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| 开始日期: | 2017-08-15
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| 结束日期: | 2020-07-31
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| 资助金额: | 116150
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| 资助来源: | US-NSF
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| 项目类别: | Continuing grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | project
; phosphate-based
; novel composition
; nano-silica
; vertebral body compression fracture
; calcium phosphate-based orthopedic cement
; experimental study
; osteoporotic bone
; mechanical characteristic
; calcium phosphate-based injectable orthopedic cement
; mentoring program
; biomechanical model
; osteoconductive property
; spinal model
; medical device regulation
; specific scientific objective
; resorption kinetics
; biomaterial development
; dicalcium phosphate anhydrous
; bhadurithis project
; co-op program
; next generation
; fracture site
; calcium phosphate-based orthopedic cement composition
; severe pain
; cement
; simple chemical
; bone morphogenic protein release
; bone morphogenic protein
; various cement composition
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| 英文摘要: | Award # 1706513
PI: Bhaduri
This project will develop and characterize a novel material for the treatment of vertebral body compression fractures. This debilitating condition of the spine causes severe pain, reduced mobility, and potentially compromised organ function in a diverse segment of the population. The team will develop a next-generation, calcium phosphate-based orthopedic cement composition that, when injected at the fracture site, self-sets and develops strength within a short time without any generation of heat that could damage the surrounding tissue. Furthermore, the new material will be designed such that it has the ability to induce bone growth at the site of the fracture, which will improve healing. The innovation in this project is related to both the processing of the material and the choice of compositions. Working together, these two aspects of biomaterials development will create novel compositions with a diverse range of capabilities. These newly developed and optimized materials will be tested in a biomechanical model to mimic both normal and osteoporotic bone. The new material is expected to be cost effective, as the starting materials are simple chemicals. This project will integrate students of all levels, from high school through graduate students, into the laboratory. In addition, a mentoring program will be established with inner-city Toledo high schools to excite students about STEM fields, particularly related to bioengineering and manufacturing. Finally, a co-op program for undergraduate students will be developed in conjunction with the FDA to provide students with experience in medical device regulation.
The goal of this project is to design, optimize, and fully characterize - including through in vitro testing - novel compositions of a calcium phosphate-based orthopedic cement. The cement will be predominantly dicalcium phosphate anhydrous (CaHPO4, also known as monetite), which has optimized resorption kinetics and so supports biodegradation of the cement as the natural bone heals. The particles within the cement will be bonded with nano-silica to provide strength and osteoconductive properties. Additional osteoconduction can be generated due to the material?s ability to deliver bone morphogenic proteins to the affected site. The specific scientific objectives will be to: 1) develop, examine, and optimize the physical and mechanical characteristics of this next generation, calcium phosphate-based injectable orthopedic cement; 2) perform experimental studies on spinal models (both normal and osteoporotic) to determine the in vitro performance of the various cement compositions; and 3) evaluate the kinetics of bone morphogenic protein release from the cement as well as its impact on cell attachment and proliferation to the material surface. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/89382
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Sarit Bhaduri. Next Generation Ca-P Cements for Treating Vertebral Body Fractures. 2017-01-01.
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