| 项目编号: | 1743607
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| 项目名称: | DCL: HBCU:EAGER- Study of Biological Interaction between Fungal Cells and Electrospun Nanofibrous Platform |
| 作者: | Lifeng Zhang
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| 承担单位: | North Carolina Agricultural & Technical State University
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| 批准年: | 2017
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| 开始日期: | 2017-07-01
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| 结束日期: | 2019-06-30
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| 资助金额: | 100000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | electrospun nanofiber
; electrospun nanofibrous mat
; fungal cell
; biological interaction
; other electrospun nano fibrous mat
; cell metabolic activity
; electrospun polyacrylonitrile nano fibrous mat
; hbcu eager
; detailed interaction information
; cell morphology
; cell number
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| 英文摘要: | DCL; HBCU EAGER: Structural and functional characterization of proteins associated with silver nanoparticle resistant Escherichia coli
In recent years, integration of electrospun nanofibers in commercial products has been growing exponentially. Electrospun nanofibers have been found in a number of applications such as air filtration, liquid filtration, performance apparel, drug delivery, scaffold for tissue engineering, battery separators and etc. The electrospun nanofibers are already exposed (and will continue being exposed) to our environment through corresponding commercial products in the form of nano fibrous mat. Inevitably, they will be in contact with microorganisms in environment, including fungi. However, little is known about biological interaction between electrospun nanofibrous mat and fungal cells. Detailed interaction information between fungal cells and electrospun nanofibrous mat from this research project will create public awareness about electrospun nanofibers' uses and their impact on environmental microorganism. Policy makers can also make use of the information to regulate the integration of electrospun nanofibers in consumer products.
The objective of this research is to explore viability and growth behavior of a model fungal cell (yeast) on electrospun polyacrylonitrile nano fibrous mat (as well as other electrospun nano fibrous mats) by cell morphology, cell number, and cell metabolic activity. The results will be compared with those from microfibrous and film counterparts. The project will provide new knowledge regarding interaction between fungal cells and electrospun nanofibrous materials by investigating the effect of chemical structure, size, surface roughness, hierarchical structure of the electrospun nanofibrous mats. The research outcomes can aid in understanding the mechanism of the biological interaction and disclose a brand-new way to realize antifungal functionality by simple physical contact without integrating any antifungal drugs or functional groups. The acquired knowledge will fill in a largely unknown research field and further translate to other nano materials that have similar structure, dimension, and/or morphology as electrospun nanofibrous materials. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/89890
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Lifeng Zhang. DCL: HBCU:EAGER- Study of Biological Interaction between Fungal Cells and Electrospun Nanofibrous Platform. 2017-01-01.
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