| 项目编号: | 1705645
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| 项目名称: | Light-enabled gene control for cardiac applications |
| 作者: | Emilia Entcheva
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| 承担单位: | George Washington University
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| 批准年: | 2017
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| 开始日期: | 2017-07-01
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| 结束日期: | 2020-06-30
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| 资助金额: | 360923
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | light-enabled gene patterning
; optical control
; optogenetic work
; gene editing tool
; local gene expression
; gene expression
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| 英文摘要: | This project will demonstrate that light-enabled gene patterning can control the human cardiac pacemaker region. Light-enabled inhibition of key culprit regions implicated in atrial fibrillation will be investigated. Exciting preliminary results on automated high-throughput all optical cardiac electrophysiology platforms using optogenetics was demonstrated and will be employed.
This project builds upon the PI's optogenetic work in optical control of cardiomyocyte function by incorporating gene editing tools (CRISPR) to allow optical manipulation of gene expression. The optical localization, using CRISPR action, will be used to modify local gene expression in cardiac tissue constructs. The proposal covers unexplored territory in cardiac pacing and has significant transformative potential. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/89952
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Emilia Entcheva. Light-enabled gene control for cardiac applications. 2017-01-01.
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