| 项目编号: | 1706322
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| 项目名称: | Bioengineering of Channelrhodopsins for Neurophotonic and Nanophotonic Applications |
| 作者: | Kenneth Rothschild
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| 承担单位: | Trustees of Boston University
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| 批准年: | 2017
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| 开始日期: | 2017-06-01
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| 结束日期: | 2020-05-31
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| 资助金额: | 520000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | potential application
; new channelrhodopsin
; bioengineering technique
; optogenetic application
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| 英文摘要: | A vital area of research that expands the scope and horizons of biophotonics is the recent discovery of new forms of channelrhodopsins (ChRs-a family of proteins that function as light-gated ion channels). ChRs have played an important role in optogenetics and the recent discovery of new channelrhodopsins from algae, has expanded the potential applications of this unique class of microbial rhodopsins. Optogenetics applications include restoring vision to the blind and uncovering the basis of a host of brain disorders including strokes, traumatic brain injury, addiction, anxiety disorders, deafness, epilepsy, Parkinson's and Alzheimer's.
At present key questions such as the molecular basis of the cation and anion selectivity, the mechanism of light-activated channel-gating and control of channel kinetics remain largely unknown. In order to answer these questions and test specific hypotheses, the PIs will utilize advanced vibrational spectroscopic and bioengineering techniques. These include low-temperature and time-resolved FTIR difference spectroscopy, confocal near-IR Raman and femtosecond visible-pulse/IR-probe spectroscopy. The research program will involve undergraduate, graduate and postdoctoral trainees. This will provide a pipeline to industry for talented engineers and scientists trained in the new field of biophotonics. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/90046
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Kenneth Rothschild. Bioengineering of Channelrhodopsins for Neurophotonic and Nanophotonic Applications. 2017-01-01.
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