| 项目编号: | 1653464
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| 项目名称: | CAREER:Engineered Diseased Myocardial Model for Cell-Based Therapy |
| 作者: | Eun Jung Lee
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| 承担单位: | New Jersey Institute of Technology
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| 批准年: | 2017
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| 开始日期: | 2017-03-01
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| 结束日期: | 2022-02-28
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| 资助金额: | 500000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | cell-based
; cell-based therapy
; cell
; model
; cell function
; repair
; diseased myocardial environment
; cell interaction
; host cell
; diseased myocardial tissue model
; novel diseased model
; myocardial infarction
; myocardial damage
; stem cell
; extracellular component
; career proposal
; career research
; well-controlled diseased myocardial model
; host extracellular matrix
; multi-phase myocardial healing
; disease model
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| 英文摘要: | PI: Lee, Eun Jung
Proposal #: 1653464
Cardiovascular disease including myocardial infarction (MI) is the leading cause of death in the Western world. Over the past decade, numerous preclinical studies and clinical trials using cell-based therapies have been performed to repair or regenerate a damaged heart. One of the major hurdles in cell-based therapy is a lack of mechanistic understanding of observed therapeutic effects. To understand the functional benefits of transplanted cells, it is imperative to study the biological activity of transplanted cells in the diseased myocardial environment. Existing models however, focus almost exclusively on mimicking the healthy cardiac microenvironment with the goal of providing a living surgical replacement. This CAREER proposal takes a principal tissue engineering approach to develop a novel diseased model in vitro in order to study multi-phase myocardial healing and repair. This model with independent control of cell and extracellular components will serve as a powerful tool to investigate the mechanisms of cardiovascular disease and repair providing a major step toward making cell-based therapies more effective for patients with heart disease. Development and wide distribution of interactive educational and training tools developed in the course of the proposed research will facilitate fundamental advances in basic STEM areas as well as in the practical application of cardiovascular tissue engineering for regenerative medicine and clinical settings.
The objective of the proposed CAREER research is to advance understanding of the underlying mechanisms of repair by cell-based therapy in injured myocardium. The proposal aims to develop an in vitro diseased myocardial tissue model recapitulating disease progression following myocardial damage. The proposed engineered disease model will function as a ventricular pump replicating key characteristics of natural or infarcted myocardium. The specific goals are to: (1) Engineer a well-controlled diseased myocardial model mimicking the first two stages of the reparative process post-MI, which is the time when most cell-based therapies are performed. (2) Determine the interaction between host cells and transplanted stem cells and (3) Investigate the mechanism of the host extracellular matrix and grafted cell interaction to understand the specific role of the local infarct environment on transplanted cell function during post-MI healing process. The results from this study will address two unknown areas that currently limit the success of cell-based therapies for cardiac regeneration. The two unknowns are (1) underlying fundamental mechanisms that drive functional integration of the transplanted cells and (2) optimal timing of the therapy. Such insights will facilitate the translation of tissue engineering solutions from the lab to patients by enhancing the practical efficacy of cell-based therapy in clinics. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/90462
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Eun Jung Lee. CAREER:Engineered Diseased Myocardial Model for Cell-Based Therapy. 2017-01-01.
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