| 项目编号: | 1653627
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| 项目名称: | CAREER: Development of Enhanced Early Photon Tomography for Cancer Staging |
| 作者: | Kenneth Tichauer
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| 承担单位: | Illinois Institute of Technology
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| 批准年: | 2017
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| 开始日期: | 2017-02-15
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| 结束日期: | 2022-01-31
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| 资助金额: | 500000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | cancer
; cancer cell
; lymph node
; agent dependent early photon tomography
; photons-to-arrive-at-the detector
; breast cancer
; cancer distribution
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| 英文摘要: | ABSTRACT: Tichauer; 1653627
Approximately 1 in 8 women in the US will develop breast cancer in their lifetime. Over 40,000 women are projected to die from the disease in 2016. Surgical resection and pathology of tumor-draining lymph nodes is the current standard for detecting whether cancer has spread. However, because of the time-consuming nature of pathological assessment, less than 1% of a typical excised node is surveyed and microscopic levels of cancer are liable to be missed. The objective of this work is to rapidly map cancer distribution in surgically excised "tumor-draining" or "sentinel" lymph nodes using a novel optical imaging technology that could guide sectioning of lymph nodes in pathology so that even microscopic levels of cancer are not missed.
The approach, named ADEPT (Agent Dependent Early Photon Tomography), combines two methods that serve to provide high sensitivity and selectivity for cancer cells within highly scattering media. First, an infrared-emitting dye perfuse the node, with one dye selectively targeted to cancer cells, while the other is nonspecific, enabling compensation for local variability in dye concentration. Second, pulse excitation combined with snapshot detection of the earliest photons-to-arrive-at-the detector are counted. To obtain 3-D reconstructions of the internal lymph node volume, the image plane is scanned through the volume. With the appropriate selection of dyes, the approach can be applied to thick tissue (up to 1 cm), with a goal of 100 um image resolution. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/90522
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Kenneth Tichauer. CAREER: Development of Enhanced Early Photon Tomography for Cancer Staging. 2017-01-01.
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