| 项目编号: | 1652150
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| 项目名称: | CAREER: Compressed Fluorescence Lifetime Imaging Microscopy |
| 作者: | Liang Gao
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| 承担单位: | University of Illinois at Urbana-Champaign
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| 批准年: | 2017
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| 开始日期: | 2017-02-01
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| 结束日期: | 2022-01-31
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| 资助金额: | 505560
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | urbana-champaign 1652150fluorescence lifetime imaging microscopy
; several live cell imaging application
; multi-target fluorescence imaging
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| 英文摘要: | Abstract
Gao,Liang
University of Illinois at Urbana-Champaign
1652150
Fluorescence lifetime imaging microscopy (FLIM) has found broad applications in biomedicine because it delivers the most direct insight into the molecular interactions of a fluorophore (a fluorescent chemical compound that re-emits light upon light excitation) with its biological environment. This project will develop a potentially transformative FLIM system fast enough to see biological effects such as neuron spiking. A new optical design course for graduates, and development of a hands-on laboratory for both undergraduates and graduates are planned.
The three key tasks are to 1) develop a high-speed, depth-resolved FLIM imager using coded excitation and dual-camera detection; 2) develop a compressed spectral FLIM (sFLIM) system for multi-target fluorescence imaging; and 3) evaluate compressed FLIM and sFLIM against benchmark systems in several live cell imaging applications. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/90556
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Liang Gao. CAREER: Compressed Fluorescence Lifetime Imaging Microscopy. 2017-01-01.
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