| 项目编号: | 1638872
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| 项目名称: | Collaborative Research: Dimensions US-BIOTA-Sao Paulo: Scales of biodiversity - Integrated studies of snake venom evolution and function across multiple levels of diversity |
| 作者: | Harold Gibbs
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| 承担单位: | Ohio State University
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| 批准年: | 2016
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| 开始日期: | 2016-09-15
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| 结束日期: | 2021-08-31
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| 资助金额: | 598242
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | rapid evolution
; venom
; venom function
; venom complexity
; venomous snake
; snake species
; venom chemistry
; venom system
; postdoctoral researcher
; advanced snake
; venom evolvability
; diversification study
; divergent venom
; evolutionary radiation
; diversification
; macroevolutionary level
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| 英文摘要: | This project will determine how key innovations within the venom system have contributed to diversification in the 2,500 species of advanced snakes. Venom is hypothesized to have been the key innovation initiating the evolutionary radiation of snake species by expanding feeding opportunities. This project will seek to determine the factors and traits that promoted that diversification, and will test for biases in the genetic pathways underlying rapid evolution in venoms between closely related species. The study includes the training of two postdoctoral researchers, and multiple high school, undergraduate, and graduate students at three major state universities in Ohio and Florida. The research will produce new data on venom chemistry and function, which may be useful for novel drug discovery and design.
Representative samples of diverse species from three families of venomous snakes will be collected in the United States, Central America, and Brazil to test for relationships between venom function and diversification rates. Venom complexity, composition, and enzymatic-activity profiles will be assayed to test the hypothesis that higher venom evolvability is a prerequisite for rapid evolutionary diversification. Six closely related species pairs with highly divergent venoms will be chosen for molecular assays to evaluate the genetic and protein changes responsible for rapid evolution of venom function. This work will unite diversification studies and the genetics of adaptation to provide an integrated perspective of how adaptations are built and how they affect diversification, leading to an understanding of how biodiversity originates across micro- to macroevolutionary levels. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/90940
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Harold Gibbs. Collaborative Research: Dimensions US-BIOTA-Sao Paulo: Scales of biodiversity - Integrated studies of snake venom evolution and function across multiple levels of diversity. 2016-01-01.
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