| 项目编号: | 1605177
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| 项目名称: | GOALI: Predicting Biofilm Deformation and Detachment Using In-Situ Micro-Rheology and Phase-Field Modeling |
| 作者: | Robert Nerenberg
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| 承担单位: | University of Notre Dame
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| 批准年: | 2016
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| 开始日期: | 2016-07-15
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| 结束日期: | 2019-06-30
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| 资助金额: | 329889
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | mechanical property
; detachment
; biofilm
; biofilm deformation
; bacterial biofilm
; understanding
; pure-culture biofilm
; novel phase-field model
; co-culture biofilm
; micro-scale spatial variability
; nitrifying biofilm
; novel information
; biofilm research
; zeelung membrane aerated biofilm reactor
; environmental biofilm
; gelatinous biofilm
; counter-diffusional biofilm
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| 英文摘要: | 1605177
Nerenberg
It is recognized in environmental technology and processes that bacterial biofilms play an important role. However, the understanding of how they are formed, their mechanical strength, and, in many cases, their contribution to actual changes which are observed in the environment, are poorly understood. To gain a better understanding of bacterial biofilms, this research will characterize the mechanical properties of biofilms, especially counter-diffusional biofilms relevant to the ZeeLung Membrane Aerated Biofilm Reactor from GE Power and Water, to allow prediction of biofilm deformation and detachment.
Biofilm deformation and detachment remains a black box, where there are no reliable and mechanistic means to predict them. Also, few researchers have considered the viscoelastic behavior of biofilms. This research will determine the mechanical properties of heterotrophic, nitrifying, and combined heterotrophic and nitrifying biofilms, considering their viscoelastic behavior. It uses a unique, in-situ micro-scale technique to assess the spatial distribution of mechanical properties. In addition to studying pure-culture biofilms, this study will be the first to address the mechanical properties of a co-culture biofilm, where a known nitrifier and heterotrophs co-exist. The pure and co-culture results will be compared with an environmental biofilm at GE. The composition of the extracellular polymeric substance matrix will be determined in-situ and related to mechanical properties. The properties will be assessed as a function of time and shear stress, and also will assess the effect of an extracellular polymeric substance disruptor on mechanical properties. This is the first research to address the micro-scale spatial variability of biofilms relevant to environmental systems. It will also address a special type of tubular, sheath structure observed in heterotrophic, counter-diffusional biofilms, leading to dense, gelatinous biofilms. The research will develop novel information on the spatial and temporal variation of mechanical properties in biofilms under several environmentally relevant conditions, and will relate these properties to extracellular polymeric substance characteristics. It also will use a novel phase-field model to predict deformation and detachment, and the impact of spatial heterogeneity.
The project will train one doctoral student, several undergraduate researchers and research experiences for undergraduate students, and partially support a post-doctoral researcher. It will provide an on-site experience at GE for a grad student or post-doc. Workshops between Notre Dame and GE will disseminate knowledge on biofilm research and process development at a global membrane process company, and promote local workforce development. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/91764
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Robert Nerenberg. GOALI: Predicting Biofilm Deformation and Detachment Using In-Situ Micro-Rheology and Phase-Field Modeling. 2016-01-01.
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